ARECA CATECHU L. EXTRACT 295 Accell Vol. ' 12KV ! Magnification ' X 30 Figure 6. The wrinkles of the skin surface before treatment ]mill •" Accell Vol. ' 12KV Magnification ß X 30 . .. Figure 7. The wrinkles of the skin surface after treatment The wrinkles decrease in depth after application of the treated cream (3% CC-516).
296 JOURNAL OF COSMETIC SCIENCE conceived at several levels. It significantly improves the characteristics of the extracel- lular matrix, which constitutes the major dermal supporting element. We found en- hanced skin elasticity and anti-wrinkle efficacy in a cream containing 3% CC-516. Moreover, its effect on collagen synthesis results in CC-516 being qualified as a restruc- turing agent, namely by stimulating the collagen synthesis by 120% for 0.1% concen- tration. This medicinal plant extract is able to preserve collagen and elastin fibers against degradation by hydrolyric enzymes. CC-516 is a new, plant-based, biological elastase inhibitor system and enhances synthesis of the proteins of the extracellular matrix (repairing role). CC-516 can be developed as an anti-aging agent for human skin. In conclusion, we suggest that CC-516 as an active ingredient for anti-aging may be sufficient to satisfy consumers and cosmetic scientists. REFERENCES (1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) (13) (14) (15) (16) (17) (18) (19) (20) (21) (22) (23) (24) (25) (26) (27) (28) (29) (3O) (31) (32) (33) (34) (35) K. Motoyosh and M. Takenouch, Proceedings of the 19th IFSCC Congress, R053, Sydney, Australia, 1996. D. L. Bissett, Photochem. Photobid., 46, 367-378 (1987). F. X. Maquart, L. Pickart, and J.P. Borel, FEBS Lett., 238, 343-346 (1988). D. E. Philip and R. B. Peter, Med. Res. Rev., 14(2), 127-197 (1994). C. T. Suresh and R. S. Sanford, Biochemistry, 29(42), 9970-9977 (1990). V. Bizot-Foulon, G. Godeat, and W. Horneveck, Int. J. Cosmet. Sci., 17, 255-264 (1995). J. Yamahara, Chem. Pharm. Bull., 27, 1464-1468 (1979). Centro Tecnico Res Pharma, Cosmetic News N., 71, 88-90 (1990). S. B. Mahato, A. N. Ganguly, and N. P. Sahu, Phytochemistry, 21, 959-978 (1982). F. Annoni, A. Mauri, and L. F. Resele, Arzneim. Forsh./Drug Res., 29, 672-675 (1979). R. Mattei, M. Carini, and P. Bonadeo, Acta Ther., 16, 337-349 (1990). A. Oldberg, P. Antonsson, and D. Henegard, Bloch. Soc. Trans., 18, 789-792 (1996). H. Muir, Bloch. Soc. Trans., 11,613-622 (1983). H. Muir, Am. J. Physiol., 18, 787-789 (1990). W. Nanen, D. N. Granger, and P. R. Kvietys, Am. J. Physiol., 259, 925-931 (1990). L. W. Wattenberg and L. K. T. Lark (Pienun Press, New York, 1981). Y. S. Kim, Y. K. Noh, and K. R. Min, Kor. J. Pharma., 26(3), 265-272, (1995). K. K. Lee, J. H. Kim, J.J. Cho, and J. D. Choi, Int. J. Cosmet. Sci., 20, 1-12 (1998). Y. Y. Shiau and H. W. Kwan, Oral Surg., 47,453 (1979). I. Dockrat and M. Shear, 4th Proc. Int. Acad. Oral Path. (Gordon and Breach Science Publishers, Inc., New York, 1970), p. 57. V. Raghavan and H. K. Baruah, History, chemistry and utilization, Econ. Bat., 12, 315-325 (1958). K. K. Wary and R. N. Sharan, 22nd Annual Meeting of ESRB, Brussels, September 11-17, 1989. IARC, Mon graphs on the evaluation of the carcinogenic risk of chemicals to humans, International Agency for Research on Cancer, Lyon, 37, 5-269 (1985). O. H. Lowry, N.J. Rosebroungh, A. K. Fart, and R. T. Randall, J. Biol. Chem., 193, 256 (1951). M. Dobois, K. A. Glles, and F. Smith, Analyt. Chem. 28, 350 (1956). D. G. Roux, J. Soc. Leather Trades Chemists, 35, 322 (1951). A. E. K. James, D. W. Timothy, and L. Gordon, Biochemistry, 35, 9090-9096 (1996). L. Donald, V. Thomas, J. Orr, Photochem. Photobiol., 46(3), 367-378 (1987). B. Coulomb, L. Dubertret, and E. Bell, J. Invest. Dermatol., 81, 75-78 (1983). T.J. Mosmann, Immunol. Methods, 63, 55 (1983). F. X. Maquart, FEBS Lett. 282, 343-346 (1988). R. F. Diegelmann and B. Peterkofsky, Biochemistry, 10, 988-994 (1971). R. F. Diegelmann and B. Peterkofsky, Dev. Biol., 28, 443-453 (1972). W. Courage, "Hardware and Measuring Principle: Corneometer," in Bioengineering of the Skin: Water and the Stratum Corneum, P. Elsner, E. Berardesca and H. H. Maibach, Eds. (CRC Press, Boca Raton, FL, 1994), pp. 171-176. A. Barel and P. Clarys, in J. Setup and G. B. E. Jernec, Eds. (CRC Press, Boca Raton, FL, 1995), pp. 165-197.
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