GROWTH INHIBITION OF CORYNEFORM BACTERIA 219 by reliably inhibiting the growth of coryneform bacteria, the main producers of odorous substances from underarm sweat and skin surface lipids. In addition, it is composed of natural products and has shown no signs of sensitization, i.e., of allergic contact eczema (3). HGQ and its individual natural active substances are biologically degradable to an acceptable degree. Only CO• and H20 are formed, since there is no nitrogen contained in HGQ. Furthermore, this finding indicates that although the synergistically acting HGQ mix- ture has a selective bactericidal action, it is degraded naturally after use, which is not true of the first generation of deodorants. REFERENCES (1) M.P. Coyle and B. A. Lipsky, Coryneform bacteria in infectious diseases: Clinical and laboratory aspects, Clin. Microbiol, Rev. 3, 227-246 (1990). (2) A. Dravnieks, B. K. Krotoszynski, W. E. Lieb, and E. Jungermann, Influence of an antibacterial soap on various effluents from axillae, J, Soc. Cosmet, Chem,, 19, 611-629 (1968). (3) Data on file, Dragoco, Holzminden, FRG. (4) EEC, Derektive 79/831, Annex V, part C: Methods for the determination of ecotoxicity. c. 6. Degradation, biotic degradation: closed bottle test. OECD--Limit for ready degradeability: 60% within 28 days. (5) C. Froebe, A. Simone, A. Charig, and E. Eigen, Axillary realodor production: A new mechanism, J, Soc. Cosmet. Chem., 41, 173-185 (1990). (6) M. Gloor and T. Scheer, In-vivo-Regulation der Hornschichtfeuchtigkeit, ,4rtzl. Kosmetologie, 19, 31-40 (1989). (7) A. A. Hartmann, Untersuchungen zu Unterschieden der Keimzahlen der Residentflora benachbarter Hautareale in Abhiingigkeit von der benutzten, Hautfloragewinnungsmethode, ,4rtzl, Kosmetologie, 13, 142-154 (1983). (8) A. A. Hartmann, Effect of occlusion on resident flora, skin moisture and skin pH, Arch. Dermatol. Res,, 275, 251-254 (1983). (9) U.-F. Haustein, Bakterielle Hautflora, Wirtsabwehr und Hautinfektion, Dermatol, Mon. Schr. 175, 665-680 (1989). (10) G. W. Holzmer, Die Priifung der Wirksamkeit von K0rperdeodorantsprays, Aerosol Report 25, 354- 369. (11) U. Hoppe, U. Eigener, G. Sauermann, W. Engel, and W. Pape, Deodorizing and antimicrobial composition for use in cosmetic or topical formulations USP 4.921.694 (1.5. 1990). Priorities: DE 37 20 831 (24.6. 1987), DE 3740186 (27.11. 1987). (12) U. Hoppe and G. Sauermann, Moderne kosmetische Wirkstoffe und der Nachweis ihrer Funktion, Zeitschr, f. Hautkrankheiten, 65, 123-131 (1990). (13) P.J.H. Jackman and W. C. Noble, Normal axillary skin microflora in various populations, Clin. Exp. Dermatol,, 8, 259-268 (1983). (14) H. Ch. Korting, A. Lukas, and O. Braun-Falco, Mikrobielle Flora und Geruch der gesunden men- schlichen Haut, Hautarzt, 39, 564-568 (1988). (15) E. H. Lennette, A. Balows, et al, "Coryne Bactrium spp. and Other Coryneforme Organisms," in Manual of Clinical Microbiology, 4th Ed. (American Society for Microbiology, Washington D.C., 1985), pp. 193-204. (16) J. j. Leyden, K.J. McGinley, K. M. Nordstrom, and G. F. Webster, Skin microflora, J. Invest. Dermatol,, 88, 65s-72s (1987). (17) N. Liappis, S.-D. Kelderbacher, K. Kesseler, and P. Bantzer, Quantitative study of free amino acids in human eccrine sweat excreted from the forearms of healthy trained and untrained men during exercise, Eur. J. Appl, Physiol, 42, 227-234 (1979). (18) B. A. Lipsky, A. C. Goldberger, L. S. Tompkins, and J. J. Plorde, Infections caused by pendiph- theria corynebacteria, Rev, Inj$ct. Dis,, 4, 1220-1235 (1982).
220 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS (19) N. Lowicki, M. Sodillo, and O. Neunhoeffer, Primiir-Desordorierung, •rtzl. Kosmetologie, 2, 75-79 (1974). (20) A. Lukacs, H. C. Korting, G. Ruckdeschel, and W. Ehret, Do cutaneous coryneform bacteria produce short-chain fatty acids in vitro? Dermatologica, 182, 32-34 (1991). (21) G. Peter, F. SchriSpf, H. G. Feisel, and W. Thiirauf, Gaschromatographische Untersuchungen yon freien und gebundenen Fettsiiuren im ekkrinen SchweiB, Arch. Klin. Exp. DermatoL, 238, 154-159 (1970). (22) P. J. Rennie, D. B. Gower, and K. T. Holland, In vitro and in vivo studies of human axillary odour and the cutaneous microflora, Br. J. Dermatol., 124, 596-602 (1991). (23) G. Sauermann, U. Hoppe, M.-C. Leneveu, M. RiSckl, U. Stelling, and K. P. Wittern, A simple method to avoid sandiness and enhance deodorant efficacy of soaps containing TCC, J. Soc, Cosmet, Chem., 40, 75-90 (1989). (24) K. Sato, W. H. Kang, K. Saga, and K. T. Sato, Biology of sweat glands and their disorders. I. Normal sweat gland function, J. Am. Acad, Dermatol., 20, 537-563 (1989). (25) R. Wagner, Methoden zur Priifung der biochemischen Abbaubarkeit chemischer Substanzen VCH Verlagsgesellschaft mbH, Weinheim, 1988. (26) H. Tronnier, Ursach und Vermeidung yon KiSrpergeruch. Artzl. Kosmetologie, 11, 269-273 (1981).
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