COSMETIC USE OF NEW SYNTHETIC ANTIFUNGAL AGENT 577 of use. In other words, the possibility of including OD-507 in a series of preparations, either as a prophylactic against widespread epidermo- mycotic states or as a useful adjuvant to therapeutic treatment, was studied. EXPERIMENTAL Three preparations were used: a body powder, a solid skin deter- gent, and a shampoo. The body powder was formulated with 2% micronized OD-507 in a base consisting of talc, isopropyl myristate, and Carbowax 1500 to assure adhesion of the preparation. The solid skin detergent was formulated with the objective of using detergents capable of giving aqueous solutions at weakly acid pH values. A solid skin detergent based on anionic surfactants, polyethylene glycols, alcohols, and higher fatty acids was therefore prepared. Lactic acid was used to achieve the acidic pH. OD-507 was incorporated at a concen- tration of 2%. This preparation, dispersed in water at 1% concentra- tion, gives a pH of 6.5. The shampoo was formulated at a neutral pH, choosing anionic and non-ionic surfactants as detergents. The OD-507 was incorporated at 0.5% concentration. The formulations are shown below: Body Powder Talc USP XVII Isopropyl myristate (Italcolloid-Italy) Polyethylene glycol 1500 (Carbowax 1500 Union Carbide-USA) OD-507 Solid Skin Detergent Sodium laurylsulfate (Empicol L.Z.G.V. Marchon Italiana-Italy) Sodium N-oleyl-N-methyltaurate (Arkopon T. Hoechst-Germany) Stearic acid Stearyl alcohol Polyethylene glycol (Polyglycol E 401)0 I)ow Chclnical- USA) Talc USP XVII Lactic acid OD-507 95.0 g 1.0g 2.0g 2.0g 11.0 g 31.0 g 16.5g 12.0 g ll.Og 16.0 g 0.5g 2.0g

,578 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Shampoo Sodium laurylpolyoxyethylene sulfate (Salvo E02() 35. () g Chemy-Holland) Polyoxyethylene stearate (Myrj 52 Atlas-U.S.A.) 5.0 g Sodium N-alkyl-N-methyltaurate (Hostapon C.T. 10.0 g Hoechst-Germany) 0D-507 0.5 g Water to make 100.0 ml RESULTS The cosmetic preparations under test were used by subjects suffering from a variety of clinical skin mycoses which, according to past personal history, had all chronically relapsed. The case list was, therefore, a selected one and comprised primarily refractory patients. The first group consisted of 18 subjects, all suffering from dermato- phytosis between the toes (athlete's foot) chronically relapsing during the spring/summer season for three to five years. After complete clinical recovery (through use of OD-507 cream), 12 of these subjects started maintenance treatment using the solid deter- gent two to three times weekly and applying the talcum powder daily or on alternate days. The other six subjects were not treated with the cream but instead started prophylactic treatment with the solid deter- gent and the talcum powder at the start of spring, a period which, accord- ing to past personal history, consistently coincided with relapse of the mycosis. The results indicate that no fungal manifestations reappeared in any of the 18 subjects so treated. Patient tolerance of the solid detergent and the talcum powder was excellent. The second group consisted of 11 subjects with inguinal epidermo- mycosis (bilateral in 9 cases) which had repeatedly relapsed for years. All subjects applied the detergent and talcum powder systematically every day for a long period instead of ordinary soap and bath talc. As in the first group, no relapses occurred in any of the cases. The third group comprised ten subjects suffering from pityriasis versicolor which consistently relapsed in spite of varied and prolonged earlier treatments. In several cases the lesions still showed obvious fluorescence under ultraviolet light. All ten subjects made systematic and prolonged use of the solid detergent and talcum powder under test. None of the patients showed relapse of the chromophytosis. The fourth group comprised seven obese subjects, suffering from re- lapsing candidiasis of the large body folds. Two cases suffered from