INSTRUMENTATION IN THE COSMETIC LABORATORY 329 CHa groups. Carboxymethylcellulose can be recognized by its characteris- tic steplike absorptions in the 8.5-10.2 region combined with the peaks at 7.05 and 7.55 microns. Other instrumental techniques which have application in the cosmetic industry are mass spectrometry, nuclear magnetic resonance, flame pho- tomerry, emission spectrography and x-ray fluorescence spectrometry which can be used for the analysis of metallic elements down to the parts per million range. X-ray diffraction spectrometry may be applied to the determination and identification of many crystalline compounds. Isotope - \ fl IR• MOSS• • [ • ', ,/ J INFRARED • [/ • •, / / ABSORPTIONS 7 8 9 I0 II WAVELENGTH IN MICRONS Figure 7. and tracer techniques can provide dramatic demonstration of physiological performance. Electronic accessory equipment is utilitarian as well as glamorous. The mass spectrometer with automatic integrator and read- out to generate a typewritten report can be a practical luxury. Each instrumental technique contributes its own specific type of information to the total picture although no single instrument can be considered a panacea. It can be expected that the future will bring more complex and varied products from the cosmetic industry and superior methods of analysis will have to be developed in order to handle these products. Instrumentation will obviously continue to play an important role in the future. Full utilization of instrumentation can be realized only if the chemists guiding instrumentation are capable of assessing the limitations and potential of the individual instruments and recognize the need for the coordination of instrumental data with classical wet methods of analysis. Certain combinations of instruments are particularly powerful. Typical examples are gas chromatography and the mass spectrometer, or gas
30 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS chromatography and infrared or ultraviolet spectrometry. Trains of components complete simple repetitive analyses on large numbers of samples essentially unattended. All of the instruments mentioned herein are in use, in various combination and to varying degrees, in our industry. We are led to one sweeping conclusion. The entire spectrum of instrumenta- tion finds application in the cosmetic industry which, in turn, is making a vigorous contribution to instrumental techniques. ACKNOWLEDGMENT: The authors wish to thank Messrs. J. W. Jenkins, K. O. Kellenbach, E. M. Emery, L. Gildenberg and G. J. Suarez for their work on the illustrations cited in this paper. (Received June 1, 1961) REFERENCES (1) Kent, A. P., Colgate Research Report No. 1130, April 20, 1956. (2) Childs, R. F. and Parks, L. M., •t. vim. Pharm. vixxoc. Sci. Ed., 45, 313 (1956•. ALOPECIA AND CUTANEOUS ULCERATION IN RATS RESULTING FROM SUBCUTANEOUS INJECTIONS OF A SYMPATHOMIMETIC AGENT, METHOXAMINE HYDROCHLORIDE By AMOS E. LIGHT* SrrI•rULATED Br the report of Cockrem (4) that methoxamine hydro- chloride (•-hydroxy-•-(2,5-dimethoxyphenyl)-isopropylamine hydrochlo- ride) injected subcutaneously depressed the general growth of hair on mice, a series of tests using rats were o, mducted to determine the action of the sympathomimetic agent on tissue and hair growth in the area of the injection sites. Aqueous solutions and oil suspensions of the drug were compared in both male and female animals. The additional effects of sex hormones were also investigated. METHODS One per cent methoxamine hydrochloride in physiological saline solution was administered subcutaneously as the aqueous type of preparation while a 1 per cent suspension of the salt in peanut oil was used as the depot type of material. Control animals received 0.9 per cent saline solution or peanut oil alone. With aqueous solutions the animals were injected by means of a syringe equipped with a half-inch #27 gauge hypodermic needle with oil a #20 needle was used. A preliminary trial revealed that some fatalities * 49 Colonial Parkway, North Yonkers, N.Y.
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