SIMULTANEOUS GC ASSAY OF DEG AND EG 233 appropriate standards, this basic test procedure could also be useful as an assay procedure for incoming glycerin, propylene glycol, and sorbitol. REFERENCES (1) U.S. Pharmacopeia, USP 32-NF 27, May 2009. (2) USP Hot Topics, USP Propylene Glycol and Sorbitol Solution Information, http://www.usp.org/hottopics/ propyleneGlycolSorbitolInformation.html (3) Guidance for Industry, Testing of Glycerin for Diethylene Glycol, U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research CDER), May 2007. Figure 8. Five standard chromatograms overlaid, demonstrating reproducibility. Figure 9. Chromatograms from spiking study.
JOURNAL OF COSMETIC SCIENCE 234 (4) A. S. Kenyon, S. Xioye, W. Yan, and N. W. Har, Simple at-site detection of diethylene glycol/ethylene glycol contamination of glycerin and glycerin-based raw materials by thin-layer chromatography, J. AOAC Int., 81(1), 44–50 (1998). (5) http://www.fda.gov/oc/opacom/hottopics/toothpaste.html, link to “Identifi cation of Diethylene Glycol (DEG) in Toothpaste by Thin Layer Chromatography (TLC).” (6) G. G. Esposito and R. G. Jamison, Gas chromatographic determination of ethylene glycol in used crankcase oils, J. Materials, JSMLSA 5(4), 779–785 (1970). (7) Quantitative determination of 1,2-ethanediol contamination in used diesel lubricating oils by gas chro- matography/mass spectrometry, Lubrication Engineering, 48(1), 49–54 (1992). (8) K. Molever, Quantitative determination of glycerin in soap by capillary gas chromatography, J. Am. Oil Chem. Soc., 64, 1356–1357 (1987). (9) USP Announces Strengthened Glycerin Standard to Help Protect Consumers from Poisoned Products, USP, Rock- ville, Md., February 4, 2009. (10) L. Polgren, “84 Children Are Killed by Medicine in Nigeria,” New York Times, Feb. 6, 2009. (11) Guidance for Industry, Testing of Glycerin for Diethylene Glycol, U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), May 2007. (12) A. Martin, “Melamine Traces Found in U.S. Infant Formula,” New York Times, Feb. 6, 2009. (13) J. L. Little, J. Chromatogr. A, 844, 1–22 (1999). (14) J. L. Little, Eastman Chemical Company, Artifacts in Trimethylsilyl Derivatization Reactions and Ways to Avoid Them, updated 8-10-2003, http://users.chartertn.net/slittle/fi les/silyl.pdf
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