EVALUATION OF ANTIDANDRUFF FORMULATIONS 145 had no alopecia nor clinical sign of any other dermatologic disease. There were a total of 207 patients in the study group: 146 (70%) had dandruff, yet only 16 (11%) of these had only scalp seborrhea and no other skin condition. I must conclude that dandruff is a very common sign that suggests an impending abnormal behavior of the skin or its appendages. The rationales for therapeutic use of antidandruff agents is therefore sound. A formula- tion should clean the hair, free the scalp of adherent debris and regulate the amount of residual scale and oil to retain healthful scalp conditions. Antibacterial properties either inherent in the formulation or as added germicidal agents are helpful. Mild keratoplastic or keratolytic action may help regulate epidermal sloughing. TABLE IV--ASSOClATIOX BETWEEX SEBORR•EA (DANDRUFF) AND RELATED DERMATOSES (Private Practice--N. Y. City--1960 and 1961) Total Male Female Allopecia With seborrhea 75 46 29 Without seborrhea 15 6 9 With seborrhea 40 11 29 Without seborrhea 54 11 43 Psoriasis With seborrhea 7 4 3 Without seborrhea 8 5 3 Seborrhea Allone Adults without alopecia 16 7 9 Infants with food eczema 8 4 4 There have been a number of effective antibacterial agents developed, some of which compare favorably with the therapeutic standard, the selenium sulfide formulation. Further progress will come through use of antiallergens, similar in action to the topically applied corticosteroids. Not only analogs of hydrocortisone but also the sex hormones and their derivatives may prove useful. Topically applied vitamins and enzyme inhibitors may influence sebum flow. There is still room for antidandruff formulation improvement, but developmental study of each new ingredient must follow conventional design and be scrutinized on all facets of the dandruff disease process. (Received September 20, 1962) REFERENCES (1) A. C. Allen, The Skin, At Clinicopathologic Treatise, C. V. Mosby Co., St. Louis, Mo. 1954. (2) H. J. Spoor, Proc. Sci. Sect. Toilet Goods Alssoc., No. 23, 27 (1955). (3) H.J. Spoor, Eugene F. Traub, and Mary Bell, Alrch. Dermatol. and Syphilol., 69, 323 (1954). (4) H. J. Spoor, Proc. Sci. Sect. Toilet Goods Alssoc., No. 36, 20 (1961).

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