SACRAN PROTECTS SKIN AGAINST POLLUTANTS 31 (5) F. Gaboran, P. Moliere, I. Maquis, A. Moysa, M. Geze, and L. Dubertret, Membrane damage induced in cultured human skin fi broblasts by UVA irradiation, Photochem. Photobiol., 58, 515–520 (1993). (6) D. B. Menzel, The toxicity of air pollution in experimental animals and humans: the role of oxidative stress, Toxicol. Lett., 72, 269–277 (1994). (7) B. N. Ames, L. S. Gold, and W. C. Willett, The cause and prevention of cancer, Proc. Natl. Acad. Sci. U.S.A., 92, 5258–5265 (1995). (8) M. Valko, D. Leibfritz, J. Moncol, M. T. Cronin, M. Mazur, and J. Telser, Free radicals and antioxidants in normal physiological functions and human disease, Int. J. Biochem. Cell Biol., 39, 44–84 (2006). (9) M. Kampa and E. Castanas, Human health effects of air pollution, Environ. Pollut., 151, 362–367 (2008). (10) M. Lodovici and M. Bigagli, Oxidative stress and air pollution exposure, J. Toxicol., 2011, 487074 (2011). (11) R. Kohen, Skin antioxidants: their role in aging and in oxidative stress—new approaches for their evaluation, Biomed. Pharmacother., 53, 181–192 (1999). (12) C. Baudouin, M. Charveron, R. Tarroux, and Y. Gall, Environmental pollutants and skin cancer, Cell Biol. Toxicol., 18(5), 341–348 (2002). (13) A. Viekötter, T. Schikowski, U. Ranft, S. Dorothea, M. Matsui, U. Krämer, and J. Krutmann, Airborne particle exposure and extrinsic skin aging, J. Invest. Dermatol., 130, 2719–2726 (2010). ( 14) R. Kamide, L. Misery, N. Perez-Cullell, V. Sibaud, and C. Taïeb, Sensitive skin evaluation in the Japanese population, J. Dermatol., 40, 177–181 (2013). (1 5) M. S. Denison, A. A. Soshilov, G. He, D. E. DeGroot, and B. Zhao, Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) recep- tor, Toxicol. Sci., 124(1), 1–22 (2011). (1 6) T. Ikuta, T. Namiki, Y. Fujii-Kuriyama, and K. Kawajiri, AhR protein traffi cking and function in the skin, Biochem. Pharmacol., 77(4), 588–596 (2009). (1 7) M. Furue, M. Takahara, T. Nakahara, and H. Uchi, Role of AhR/ARNT system in skin homeostasis, Arch. Dermatol. Res., 306, 769–770 (2014). (1 8) T. Mizutani, H. Sumida, Y. Sagawa, Y. Okano, and H. Masaki, Carbonylated proteins exposure to UVA and to blue light generate reactive oxygen species through a type I photosensitizing reaction, J. Dermatol. Sci., 84, 314–321 (2016). (1 9) E. K. Kim, D. Cho, and J. H. Park, Air pollution and skin diseases: adverse effects of airborne particu- late matter on various skin diseases, Life Sci., 152, 126–134 (2016). (2 0) M. K. Okajima, M. Ono, K. Kabata, and T. Kaneko, Extraction of novel sulfated polysacchardes from Aphanothece sacrum, and its spectroscopic characterization, Pure Appl. Chem., 79, 2039–2046 (2007). (2 1) M. K. Okajima, T. Bamba, Y. Kaneso, K. Hirata, E. Fukusaki, S. Kajiyama, and T. Kaneko, Supergiant ampholytic sugar chains with imbalanced charge ratio form saline ultra-absorbent hydrogels, Macromol- ecules, 41, 4061–4064 (2008). (2 2) M. K. Okajima, D. Kaneko, T. Mitsumata, T. Kaneko, and J. Watanabe, Cyanobacteria that produce megamolecules with effi cient self-orientations, Macromolecules, 42, 3057–3062 (2009). (2 3) M. Doi, Y. Sagawa, T. Mizutani, Y. Okano, S. Momose, T. Tanaka, and H. Masaki, Possibilities of sacran- polyol complexes in the skin care -evaluations of chemical and physical aspects, J. Soc. Cosmet. Chem. Jpn., 51(2), 117–125 (2017). (2 4) S. Fukushima, K. Motoyama, Y. Tanida, T. Higashi, Y. Ishitsuka, Y. Kondo, T. Irie, T. Tanaka, H. Ihn, and H. Arima, Clinical evaluation of novel natural polysaccharides sacran as a skincare material for atopic dermatitis patients, J. Cosmet., Dermatol. Sci. Appl., 6, 9–18 (2016). (2 5) M. Doi, Y. Sagawa, S. Momose, T. Tanaka, T. Mizutani, Y. Okano, and H. Masaki, Topical treatment with sacran, a sulfated polysaccharide from Aphanothece sacrum, improves corneocyte-derived parameters, J. Dermatol., 44(12), 1360–1367 (2017).