IMPORTANCE OF DNA REPAIR 213 (18) M. Xia, K. Chen, X . Yao, Y. Xu, J. Yao, J. Yan, Z. Shao, and G. Wang, Mediator MED23 links pigmen- tation and DNA repair through the transcription factor MITF, Cell Rep., 20, 1794–1804 (2017). (19) D. Ferri, D. Oriol i , and E. Botta, Heterogeneity and overlaps in nucleotide excision repair disorders, Clin. Genet., 97(1), 12–24 (2020). (20) B. Bukowska and B. Karwowski, Actual state of knowledge in the fi eld of diseases related with defective nucleotide excision repair, Life Sci., 195, 6–18 (2018). (21) P. Shah, B. Zhao, L . Qiang, and Y.-Y. He, Phosphorylation of xeroderma pigmentosum group C regu- lates ultraviolet-induced DNA damage repair, Nucleic Acids Res., 46(10), 5050–5060 (2018). (22) J. Yoon, M. McArth u r, J. Park, D. Basu, M. Wakamiya, L. Prakash, and S. Prakash, Error-prone replication through UV Lesions by DNA polymerase θ protects against skin cancers, Cell, 176(6), 1295–1309 (2019). (23) M. Kusakabe, Y. Onishi, H. Tada, F. Kurihara, K. Kusao, M. Furukawa, S. I w ai, M. Yokoi, W. Sakai, and K. Sugasawa, Mechanism and regulation of DNA damage recognition in nucleotide excision repair, Genes Environ., 41, 2 (2019). (24) L. Gregersen and J. Svejstrup, The cellular response to transcription-blo c king DNA damage, Trends Biochem. Sci., 43(5), 327–341 (2018). (25) T. Strick and J. Portman, Transcription-coupled repair: from cells to sin g le molecules and back again, J. Mol. Biol., 431(20), 4093–4102 (2019). (26) E. Cambindo Botto, J. Muñoz, and M. Muñoz, Coupling between nucleotide ex c ision repair and gene expression, RNA Biol., 15(7), 845–848 (2018). (27) G. Kokic, A. Chernev, D. Tegunov, C. Dienemann, H. Urlaub, and P. Cramer, Structura l basis of TFIIH activation for nucleotide excision repair, Nat. Commun., 10, 2885 (2019). (28) S. Matsumoto, S. Cavadini, R. Bunker, R. Grand, A. Potenza, J. Rabl, J. Yamamoto, A . Schenk, D. Schübeler, S. Iwai, K. Sugasawa, H. Kurumizaka, and N. Thomas, DNA damage detection in nucleo- somes involves DNA register shifting, Nature, 571(7763), 79–84 (2019). (29) F. Kobaisi, N. Fayyad, H. Rezvani, M. Fayyad-Kazan, E. Sulpice, B. Badran, H. Fayyad-Kazan, X . Gidrol, and W. Rachidi, Signaling pathways, chemical and biological modulators of nucleotide excision repair: the faithful shield against UV genotoxicity, Oxid. Med. Cell. Long., 2019, 4654206 (2019). (30) L. de Assis, M. Moraes, and A. Castrucci, The molecular clock in the skin, its functionalit y, and how it is disrupted in cutaneous melanoma: a new pharmacological target? Cell. Mol. Life Sci., 76(19), 3801– 3826 (2019). (31) M. Drigeard Desgamier and P. Rochette, Enhancement of UVB-induced DNA damage after chronic l o w-dose UVB pre-stimulation, DNA Repair (Amst), 63, 56–62 (2018). (32) S. Miwa and R. Hoffman, Imaging DNA repair after UV irradiation damage of cancer cells in Ge l- foam® histoculture, Methods Mol. Biol., 1760, 199–203 (2018). (33) D. Paul, H. Mu, H. Zhao, O. Ouerfelli, P. Jeffrey, S. Broyde, and J. Min, Structure and mechanism of pyrimidine-pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotid e excision repair complex, Nucleic Acids Res., 47(12), 6015–6028 (2019). (34) M. Bustamante, C. Hernandez-Ferrer, A. Tewari, Y. Sarria, G. Harrison, E. Puigdecanet, L. Nonell, W. Kang, M. Friedländer, X. Estivill, J. González, M. Nieuwenhuijsen, and A. Youn g , Dose and time ef- fects of solar-simulated ultraviolet radiation on the in vivo human skin transcriptome, Br. J. Dermatol., (2019), doi: 10.1111/bjd.18527. (35) S. Freeman, A. Blackett, D. Monteleone, R. Setlow, B. Sutherland, and J. Sutherland, Quantitation of radiation-, chemical-, or enzyme-induced single strand breaks in nonradioactive DNA by alkaline ge l electrophoresis: application to pyrimidine dimers, Anal. Biochem., 158, 119–129 (1986). (36) H. Honigsmann, W. Brenner, A. Tannew, and B. Ortel, UV-induced unscheduled DNA synthesis in human skin: dose response, correlation with erythema, time course and split dose exposure in vivo, J. Phot o chem. Photobiol. B Biol., 1, 33–43 (1987). (37) Yarosh, D. Purifi cation and Administration of DNA Repair Enzymes. US Patent 5,077,211A, issued December 31, 1991. (38) Y. Sha, V. Vartanian, N. Owen, S. Mengden Koon, M. Calkins, C. Thompson, Z. Mi r afzaili, S. Mir, L. Goldsmith, H. He, C. Luo, S. Brown, P. Doetsch, A. Kaempf, J. Lim, A. McCullough, and R. Lloyd, Mod u lation of UVB-induced carcinogenesis by activation of alternative DNA repair pathways, Sci. Rep., 8(1), 705 (2018). (39) D. Yarosh, A. Rosenthal, and R. Moy, Six critical questions for DNA repair enzymes in skincare prod- ucts: a review in dialog, Clin. Cosmet. Invest. Dermatol., 12, 617–624 (2019). (40) M.-T. Leccia, C . Lebbe, J.-P. Claudel, M. Narda, and N. Basset-Seguin, New vision in photoprotection and photorepair. Dermatol. Ther., 9(1), 103–115 (2019).

JOURNAL OF COSMETIC SCIENCE 214 (41) M. Carducci, P. Pavone, G. De Marco , S. Lovati, V. Altabas, K. Altabas, and E. Emanuele, Comparative effects of sunscreens alone vs sunscreens plus DNA repair enzymes in patients with actinic kerato s is: clinical and molecular fi ndings from a 6-moth, randomized, clinical study, J. Drugs Dermatol., 14(9), 986–990 (2015). (42) V. Snaidr, D. Damian, and G. Halliday, Nicotinamide for photoprotection and skin cancer chemopre- vention: a review of effi cacy and safety, Exp. Dermatol., 28(Suppl 1), 15–22 (2019). (43) L. Guan, A. Suggs, E. Galan, M. Lam, and E. Baron, Topical application of ST266 reduces UV-induced skin damage, Clin. Cosmet. Invest. Dermatol., 10, 459–471 (2017). (44) J. Choi, W. Cho, Y. Choi, J . Kim, H.-A. Park, S. Kim, J. Park, D.-G. Jo, and Y. Cho, Functional recov- ery in photo-damaged human dermal fi broblasts by human adipose-derived stem cell extracellular ve s- icles, J. Extracell. Vesicles, 8, 1565885 (2019)