FEMALE/MALE ANTIPERSPIRANT EFFICACY 5 therefore believe it appropriate that female test panels can be used in the development of all antiperspirant products. However, when fi nal claims are being defi ned, testing should be done as directed by the regulatory agency. CONCLUSIONS Data from eight antiperspirant effi cacy studies indicated no signifi cant difference between the effi cacy achieved from males versus females. This paper indicates that gender does not have a signifi cant impact on antiperspirant effi cacy. REFERENCES (1) Food and Drug Administration, Antiperspirant drug products for over-the-counter human use, Federal Register, Final Monograph (68 FR 34273, June 9, 2003). (2) Food and Drug Administration, Guidelines for Effectiveness Testing of OTC Antiperspirant Drug Products, Dockets Management Branch {HFA-305} (August 1982). (3) P. A. Majors and J. E. Wild, The evaluation of antiperspirant effi cacy: Infl uence of certain variables, J. Soc. Cosmet. Chem. 25, 139 (1974). (4) F. H., Dietrich J. P., Bowman, G. M. Fath, and J. E. Wild, A comparison of antiperspirant data analysis methods, J. Soc. Cosmet. Chem., 44, 13–21 (1993). (5) Food and Drug Administration, Reply to Hill Top Research Request for Clarifi cation, Division of Dockets Management (HFA-305), Material for Docket No. 78N-0064. (6) J. P. Bowman and L. O. Oddo, “Historical review of antiperspirant vesting,” presented at the Annual Meeting of the Society of Cosmetic Chemists, New York (December 6–7, 2006), J. Cosmet. Sci., 58, 186 (2007). Figure 2. Sweat output (milligram output, females–males).

J. Cosmet. Sci., 60, 7–14 (January/February 2009) 7 Address all correspondence to Yiyang Dong. Moisturizing and anti-sebum secretion effects of cosmetic application on human facial skin YAN CHENG, YIYANG DONG, JUNBING WANG, MEIXIAN DONG, YUNDONG ZOU, DONGMEI REN, XIAORAN YANG, MING LI, ANDREAS SCHRADER, MATHIAS ROHR, and WEI LIU, Beijing Sino-German Union Cosmetic Institute Co., Chinese Academy of Inspection and Quarantine, Beijing, Peoples Republic of China 100123 (Y.C., Y.D., J.W., Y.Z., D.R., X.Y., M.L.), Procter & Gamble (China) Ltd., Guangzhou, Guangdong, Peoples Republic of China 510620 (M.D.), Institute Dr. Schrader, Holzminden, Germany D-37603 (A.S., M.R.), and Department of Dermatology, General Hospital of Air Force, Beijing, Peoples Republic of China 100036 (W.L.). Accepted for publication September 29, 2008. Synopsis For human skin, high water content and low sebum secretion are considered to be main features of fair skin. To explore the proper personal care regimen for facial skin, we investigated the change of skin physiologic pa- rameters after cosmetic application by measuring the skin water content, transepidermal water loss, and skin sebum secretion on facial skin before and after the cosmetic application using the Corneometer, Tewameter, and Sebumeter, respectively. The results indicated that the cosmetics application kept a higher water content and a lower transepidermal water loss, and at the same time, a lower sebum secretion 4 h and 8 h after the cosmetic application, compared with those before it. The situation was maintained in the succeeding three- week continuous use of the cosmetics. It could be concluded that the cosmetic application on human facial skin might provide some moisturizing effect and at the same time an anti-sebum effect, which favors the mainte- nance of good skin physiological function after applying skin care products. Our results might provide a scientifi c personal care regimen for human facial skin to prompt the balance for the hydrolipid fi lm on skin. INTRODUCTION The hydration in the surface layer of the skin, stratum corneum (SC), gives important information on the biophysical properties and function of the skin barrier (1). With an adequate amount of water in the SC, the skin maintains its intact barrier function, feels soft and fl exible, and looks smooth and healthy. Additionally, the human face is covered by a lipid fi lm. Sebum excreted from the sebor- rheic glands keeps the skin surface supple and moist, and is known to control moisture