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J. Cosmet. Sci., 60, 45 (January/February 2009) 45 SKIN BARRIER: CHEMISTRY OF SKIN DELIVERY SYSTEMS, Johann W. Wiechers, Ed. (Allured Publishing Corp., Carol Stream, IL, 2008), 658 pp. This is a ponderous book, a compilation of over 650 pages, including 61 articles that have appeared in various Allured mag- azines over the last several years plus two new chapters written specifi cally for this book. The authors include many well- known authorities in this fi eld, including the editor, Johann Wiechers, as well as Joel Zatz, Howard Maibach, and many others. As should be expected, this collection of review articles gives an extensive review of the fi eld, but some are superfi cial in depth. The reference list at the end of each chapter, however, allows the reader who is interested in an in-depth description of a particular as- pect to dig deeper. Depending on the date of the review, the references can be up-to-date or, unfortunately, quite old. Thus, the latest article cited in Chapter 6 is eleven years old! In almost three-fourths of the chapters the date of the most recent citation was at least fi ve years old. This means that a researcher intending to do research in this fi eld and ex- pecting to use this book as a starting point will fi nd that he will still need to conduct a traditional literature search to bring him- self up-to-date. For the cosmetic chemist who wishes to formulate with skin penetra- tion in mind (either to aid or avoid skin pen- etration of specifi c ingredients), these articles provide a ready source of information. As the editor, Johann Weichers, points out in his introductory chapter, skin pene- tration can be either a benefi t or a danger for ingredients in a topical preparation, de- pending on whether one is striving to cause penetration of a benefi cial substance or hoping to prevent penetration of a toxic substance. In this regard, there is little in- formation or discussion of the toxic effects of absorbed substances or the regulatory as- pects of skin absorption of substances that can have pharmacological or toxic effects.. The book is divided into three sections. The fi rst section is an introduction, which consists mainly of the basics of skin pene- tration and the practical means of avoiding or enhancing skin penetration. The second section is on delivery sys- tems, including emulsions, vesicles, encap- sulation, and miscellaneous systems such as wipes, iontophoresis, aerosol foams, and patches. It also includes a chapter on deliv- ery systems for home air aromas and two chapters on producing textiles with fra- grance materials, a bit of a stretch for a book on the skin barrier. The third section is entitled “Special Chemistry in Delivery Systems” and in- cludes chapters on emulsions as skin deliv- ery systems and on silicones. There are also four papers on solvents, surfactants, and polymers. Overall, the book is interesting, and contains a wide spectrum of information on skin delivery systems and their applica- tions to cosmetics and cosmeceuticals. It serves as a reasonable starting point for a cosmetic chemist interested in formulat- ing for, or avoiding, skin penetration. —HERMAN E. JASS—Jass Associates. Book Review