All scientists, academicians, policy makers and other stakeholders in the cosmetic and personal care community are invited to submit an abstract of original work, lab demonstration or case study for consideration as a podium lecturer. ABSTRACT SUBMISSION DEADLINE: APRIL 4, 2022 We are seeking abstracts covering the following topics: Claims / Regulations Indie Beauty Diversity in Beauty Looking to the Future / Biotech Fragrance and Sensory Makeup & Sunscreen Functional Skincare Sustainability Hair & Scalp For more information, visit the SCC website at www.scconline.org/SCC76 Accepted speakers shall receive one (1) complimentary daily access registration to the Annual Meeting for their use the day of their presentation. A full access registration upgrade for speakers is available at a discount if they wish to attend the entire meeting. Additional registrations may be purchased at the then-current rate.

499 Address all correspondence to Fernanda Daud Sarruf, fernanda.sarruf@usp.br Influence of Menstrual Cycle on Aromatic Composition Behavior After Skin Application by Gas Chromatography/Mass Spectrometry CLAUDIA S. C. P. DA COSTA, MARCUS T. SCOTTI, FERNANDA D. SARRUF, PAULO R. H. MORENO, ANDRÉ R. BABY AND MARIA V. R. VELASCO School of Pharmaceutical Sciences, University of São Paulo, 580 Prof. Lineu Prestes av., 05508-900, São Paulo, SP, Brazil (C.S.C.P.dC., F.D.S., A.R.B., M.V.R.V) Institute of Chemistry, University of São Paulo, 748 Prof. Lineu Prestes av., 05508-000, São Paulo, SP, Brazil (P.R.H.M) Centre of Science Applied and Education IV North Coast, University of Paraíba, da Mangueira s/n street, Centre, 58297-000 - Rio Tinto, PB, Brazil (M.T.S.) Givaudan® (Givaudan, Vernier, Switzerland) do Brasil, Av. Engenheiro Billings, 2185, Jaguaré, São Paulo, Brazil (C.S.C.P.dC.) Accepted for publication August 2, 2021. Synopsis Hormone secretion during the menstrual cycle changes per phase, influencing skin characteristics. These cutaneous modifications alter applied fragrances’ behavior. This research aimed at analyzing the influence of menstrual cycle phases on a fragrance’s volatile components’ variation after skin application on women. We analyzed the variation of the emitted volatile components from an aromatic composition applied on the skin of 29 female participants during all menstrual cycle phases (follicular, ovulatory, luteal, and menstrual). The emitted volatiles were collected immediately after application and at intervals of 1 h 30 min, 3 h, 4 h 30 min, and 6 h, in a tube filled with Tenax® (Tenax Therapeutics, Morrisville, NC) coupled to a thermal desorption unit. The components were analyzed by gas chromatography/mass spectrometry. The raw ion- chromatogram data after “area normalization” were tested to principal components analysis and chemometrics tools. Statistical analysis showed no distinct variance pattern among the samples collected at different hormonal phases. However, the analysis of the individual scorer plots showed a distinct pattern for the release of aromatic compounds specific to each subject and associated with menstrual cycle phase. Although the results did not generate a model for skin’s release of aromatic compounds in the population, the data showed that sex hormones have a unique effect on skin. INTRODUCTION Fine perfumery involves inspiration and sophistication and competes in the domestic and international markets. It is inserted in a competitive market with different fragrances J. Cosmet. Sci., 72, 499–510 (September/October 2021)