74 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS paper, respectively being used. For these studies the normal perspiration is generally sufficiently abundant, thus precluding the need for pilocarpine. The effect on the arm of various solutions, such as aluminum or magnesium salts, or drugs known to coagulate proteins, has been studied. It can be seen in Table 3 that aluminum chloride and aluminum nitrate are the only drugs acting on the sweat secretion, while magnesium chloride acts only to a certain extent. Solutions of aluminum chloride with or without a wetting agent were compared in the axilla. A significant influence of the wetting agent on the effect of the drug was noted (2). PROTECTIVE ROLE OF THE SEBACEOUS LAYER (9) By a similar procedure, experiments can be carried out showing the protective role of the sebaceous layer. If an aluminum chloride solution without a wetting agent is applied on a site cleaned by means of ether Action of AIC! 3 solution on the skin [degreased and not degreased] cases 10 cases Figure 5.

STUDIES ON PERSPIRATION 75 alcohol and on a symmetrical site which has not been cleaned, by the action of aluminum chloride on the sweat gland, it can be observed whether the sebum has prevented the penetration of the solution or not. For this, a locally induced perspiration by ionophoresis of pilocarpine and a Prussian blue test paper is applied on each of the sites treated. In a group of ten men and ten women of twenty to thirty years (the age group where the sebaceous layer is high), a significant difference between the formerly cleaned and noncleaned sites is noted (see Fig. 5). Thus, it can be seen that the sebaceous layer protects the skin against the action of an aluminum chloride solution. Figure 6. INFLUENCE OF AGE AND SEX ON PERSPIRATION Figure 7. INFLUENCE OF AGE AND SEX ON PERSPIRATION I significant S 0 [ e (• di[[ePence