JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Figure 8. INFLUENCE OF AGE AND SEX ON PERSPIRATION difference PHYSIOLOGY OF PALMAR, PLANTAR AND AXILLARY PERSPIRATION (5, 7) The tests described have also permitted the authors to study systemat- ically the influence of age and sex on the intensity of the palmar, plantar and axillacy perspiration in the normal subject. The study of approximately 200 persons has given the following results. Palmar and plantar perspiration decreases with age. Abundant in children and adolescents it decreases little by little to become scanty in old people (see Figs. 6 and 7). On the other hand, the statistical analysis shows a correlation between the intensity of the "hand" and "feet" tests, even if the influence of age is excluded. This means that it is very probable that persons who perspire abundantly on the hands also show strong perspiration of the feet. The axillacy perspiration shows a different curve in that it is at first nonexistent or slight until puberty, abundant in young adults and then diminishes in function according to age from thirty years onwards in men and from fifty years onwards in women (Fig. 8). CONCLUSION In order to investigate the physiology of perspiration or the action of •tntiperspirants, it is indispensable to elaborate methods of investigation (tests). Only objective tests will give some value to the results obtained. The clinical observations, if possible, should always be controlled by a test. The results of the tests, on the other hand, should be controlled clinically.

USE IN COSMETICS OF FURYLGLYCINE 77 REFERENCES (1) Minor, V., ?erh. l. Internat. Neur. Kongr., 341 (1932) Zblt. Haut u. Geschl., 44, 727 (1933) (2) Manuila,L., Dermatologica, 100, 304 (1950). (3) Manuila, L., and Islet, H., Ibid., 102, 302 (1951). (4) Brun, R., and Manuila, L., Ibid., 104, 267 (1952). (5) Brun, R., and Grasset, N., Ibid., 112, 357 (1956). (6) Brun, R, and Fayre, F., Ibid., 108, 257 (1954). (7) Brun, R., and Domine, E., Atcta Dermato-F'enereol., 38, 91 (1958). (8) Brun, R., and Hunziker, N., Dermatologica, 110, 245 (1955). (9) Brun, R., and N. Hunziker, Ibid., 114, 177 (1957). THE USE IN COSMETICS OF A NEW SYNTHETIC AMINO ACID: FURYLGLYCINE By B. Cocc^, P. RovEsT and G. Presented September 10, 1958, International Symposium, Milan, Italy RECE•TI•¾ (1) wE REPORTEl) on the action of three new synthetic amino acids: d/-1-amino cyclohexane carboxylic acid, d/-1-amino 3- methyl carboxylic acid and d/-1-amino cyclopentane carboxylic acid. The results obtained have induced us to continue further studies in this field. This time we have kept in mind the economic factor which plays an important part in our industry. The studies have been directed toward the synthesis of an amino acid, furylglycine, whose basic material, furfural, is economically produced. Furfural is easily obtained from a variety of waste products, such as bran, straw, olive husks, wild plants, etc. On the other hahd, the chemical structure of furylglycine is of particular interest because there is a heterocyclic nucleus with a lipophilic charac- teristic linked to the amino and carboxylic functions (which are definitely hydrophilic). We have also studied the action on the skin of the intermediate product in the synthesis of furylglycine (I), that is 5-furylhydantoin (II). I II Quite a number of research workers having observed the close relation- ship between hydantoins and alpha amino acids, have suggested that hydantoic acids and hydantoins might be present in proteins. * Piazza Amendola 1, Milan, Italy. Instituto di Ricerche su Derivati Vegetali, Milan, Italy.