DERMAL TOXICITY OF SODIUM LAURYL SULFATE 147 580 4- 138 rag. per kg. Spinal transection in rabbits blocked all motor manifestations without effectively modifying the respiratory collapse. Subacute derreal administration over a 90-day period of approximately 1, 10 and 25% of the acute L.D.50 value failed to produce the acute symptoms or any other manifestations of clinical or dose-related tissue pathology. The data support the absence of a cumulative effect following repeated daily applications of sodium laury] sulGte. (Received September 25, 1963) REFERENCES (1) O. G. Fitzhugh and A. A. Nelson, y. •dm. Pharm. •dssoc. Sci. Ed., 37, 29 (1948). (2) K. J. Olsen, R. W. Dupree, E. T. Plomer and V. K. Rowe, 5 e. Soc. Cosmetic Chemists, 13, 469 (1962). (3) l.. C. Miller and M. l.. Tainter, Proc. Soc. Exptl. Biol. 3•red., 57, 261 (1944).

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