508 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS packages, but also publication of test methods and protocols so that they may be judged by the international jury of fellow-scientists. Extending the demand for substantiation to the emotional values and the interaction terms is a challenge not only to us, but also to authorities who seek to reduce a matter of high emotional content to millilitres and picogrammes. Yet are we not concerned in our business of providing 'social anal- gesics' with the very quality of life? (8). And safeguarding this is one of the most important challenges to industry now and in the future. If, as I believe, industry will eventually spend a larger proportion of its resource on research for the good of the quality of life of the community, the evaluation scientist will be leading the way (9). For he, or she, will be trying to measure our success. Success to-day has already been greater than many people appreciate and my final plea is that Evaluation Science be given responsible, forward- looking, support from all concerned. (Received: 6th March 1975) REFERENCES (1) Horowitz, H. S., Baume, L. J., Backer Dirks, O., Davies, G. N. and Slack, G. L. Principal requirements for controlled clinical trials of caries preventive agents and procedures. Intern. Dental J. 23 506 (1973). (2) Wedderburn, D. L. and Prall, J. K. Hair product evaluation: from laboratory bench to consumer and back again. J. $oc. Costnet. Chem. 24 561 (1973). (3) Prall, J. K. Evaluation of the effectiveness of cosmetic shampoos. Preprint of scienti/ic papers, 6th congress of the IFSCC, Barcelona, 2 958 (1970). (4) Bull, W. H., Callender, R. M., Pugh, B. R. and Wood G. D. The abrasion and cleaning properties of dentifrices. Brit. Dental J. 125 331 (1968). (5) Wilkinson, J. B. and Pugh, B. R. Toothpastes--cleaning and abrasion. J. Soc. Cosmet. Chem. 21 595 (1970). (6) IFSCC Constitution: Article I, Section 2, para. (f). J. Soc. Cosmet. Chem. 20 227 (1969). (7) Cosmetics industry faces up to the threat of restrictive legislation. Chem. Drug. 202 296 (31 Augus0 (1974). (8) The Time.t: 30.8.74. (9) Wilkinson, J. B. Industrial R & D--the changing environment. Chem. Br#. 9 264 (June) (1973).

J. Soc. Cosmet. Chem. 26, 509-522 (1975) ¸ 1975 Society of Cosmetic Che•nists of Great Britain Cough irritation by deodorant sprays E. M. STAAL, W. BREE and P. L. C. A. RIJNBEEK* Synopsis--The causes of RESPIRATORY IRRITATION provoked by DEODORANT SPRAYS have been investigated. For this purpose, the irritant potential of several deodorant spray formulations was determined. The quantitative evaluation of cough stimulation was carried out on a large number of subjects. The various features of the method are discussed in detail. This investigation has shown that the main causes of cough stimulation by deodorant sprays are the antimicrobial agents included in the formulae. INTRODUCTION Cough, triggered by inhalation of an aerosol, is a common mani- festation, very tiresome for the user it should be considered as a technical defect of the aerosol, particularly with aerosols for cosmetic use sprayed towards the body. Cougl• is caused by irritation of the mucous membranes of the nose, throat and respiratory tract. With aerosols, in some circumstances, the sprayed contents may trigger such an irritation. The chemical and pharma- cological bases of this irritation are hardly known. Previous investigation (1, 2, 3, 4, 5, 6) refer mainly to inhalation toxicity in general terms. For this reason, the investigation described here on the causes of cough stimu- lation has been focused on formulation characteristics of aerosols and * Research Laboratory Drogerijen Maatschappij Brabantsestraat 17, Amersfoort, The Nether- lands. 5O9