PERCUTANEOUS ABSORPTION 5 3 180 al 150.. 120- 90- 60- 30- 04 o I I I I I I 20 30 40 50 60 lO 80 90 time [rain] Figure 2. Blood levels of 1 (O) und 2 (&). previously mentioned effects of lavender oil may be based partly on sufficient absorption through the skin. ACKNOWLEDGMENTS We would like to thank the Fonds zur F/Srderung der wissenschaftlichen Forschung (projects P6090C and P8299-CHE) and Dragoco Company, Vienna-Liesing, for the Table I Pharmakokinetic Parameters of 1 and 2 Parameter 1 2 Dose [mg] 7.23 8.64 kg [kg] 60.00 60.00 k(in) [1/mini 0.11 0.11 k(el) [1/mini 0.46 0.48 ti/= in [mini 6.16 6.29 tv= biol [mini 13.76 14.30 t(p) [mini 18.76 19.55 c(tp) [ng/ml] 121.08 100.17 AUC(o_9o ) [(ng/ml)min] 4927.25 4174.50 kg, body weight k(in), invasion rate constant k(el), elimination rate constant tl/2 in, half life of invasion tv2 biol, biological half life t(p), time to reach the peak c(tp), concentration at the time to reach the peak AUC(o_9o), area under the curve (0 bis 90 min).

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