JOURNAL OF COSMETIC SCIENCE 266 (2) C. D. Vi llarama and H. I. Maibach, Glutathione as a depigmenting agent: an overview, Int. J. Cosmet. Sci., 27, 147–153 (2005). (3) A. Meist er and M. E. Anderson, Glutathione, Annu. Rev. Biochem., 52, 711–760 (1983). (4) M. I. Rendon and J. I. Gaviria JI. Review of skin-lightening agents. Dermatol. Surg., 31, 886–889 (2005). (5) F. Alena , W. Dixon, P. Thomas, and K. Jimbow, Glutathione plays a key role in the depigmenting and melanocytotoxic action of N-acetyl-4-S-cysteaminylphenol in black and yellow hair follicles, J. Invest. Dermatol., 104, 792–797 (1995). (6) N. A. Za inol, T. S. Ming, and Y. Darwis, Development and characterization of cinnamon leaf oil nano- cream for topical application, Indian J. Pharm. Sci., 77, 422–433 (2015). (7) D. Stemp ak, S. Dallas, J. Klein, R. Bendayan, G. Koren, and S. Baruchel, Glutathione stability in whole blood: effects of various deproteinizing acids, Ther. Drug. Monit., 23, 542–549 (2001). (8) F. Shake el, S. Baboota, A. Ahuja, J. Ali, and S. Shafi q, Skin permeation mechanism of aceclofenac using novel nanoemulsion formulation, Pharmazie, 63, 580–584 (2008). (9) W. E. Ba warski, E. Chidlowsky, D. J. Bharali, and S. A. Mousa, Emerging nanopharmaceuticals, Nano- medicine, 4, 273–282 (2008). (10) Z. Hu, M. Liao, Y. Chen, Y. Cai, L. Meng, Y. Liu, N. Lv, Z. Liu, and W. Yuan, A novel preparation method for silicone oil nanoemulsions and its application for coating hair with silicone. Int. J. Nano- medicine, 7, 5719–5724 (2012). (11) A. Loha ni, A. Verma, H. Joshi, N. Yadav, and N. Karki, Nanotechnology-based cosmeceuticals, ISRN Dermatol., 2014, 1–14 (2014). (12) A. M. M . Eid, N. A. Elmarzugi, and H. A. El-Enshasy, Preparation and evaluation of olive oil nano- emulsion using sucrose monoester, Int. J. Pharm. Pharm. Sci., 5, 434–440 (2013). (13) E. Tron coso, J. M. Aguilera, and D. J. McClements, “Development of nanoemulsions by an emulsifi cation- evaporation technique,” in Food Process Engineering in a Changing World: Proceedings of the 11th Inter- national Congress on Engineering and Food, May 22–26, 2011, Athens, Greece, 2011, pp. 929–930. (14) D. B. Harry and S. L. Mayron, Pharmaceutical preparations of glutathione and methods of administration thereof. U.S. Patent No. 6,896,899. 24 May 2005. (15) M. Saji d, M. Sarfaraz, N. Alam, and M. Raza, Preparation, characterization and stability study of dutasteride loaded nanoemulsion for treatment of benign prostatic hypertrophy, Iran J. Pharm. Res., 13, 1125–1140 (2014). (16) A. Ali, N. Akhtar, H. Muhammad, and S. Khan, Assessment of physical stability and antioxidant activ- ity of polysiloxane polyalkyl polyether copolymer-based creams, J. Chem., 2013, 1–7 (2012). (17) A. Ali and N. Akhtar, Changes in the characteristics of water-in-oil-based high internal phase emulsion containing Moringa leaves extract at various storage conditions, Trop. J. Pharm. Res., 13, 677–682 (2014). (18) N. M. H adzir, M. Basri, M. Basyaruddin, A. Rahman, A. B. Salleh, R. Noor, Z. Raja, A. Rahman, and H. Basri, Phase behaviour and formation of fatty acid esters nanoemulsions containing piroxicam, AAPS Pharm. Sci. Tech., 14, 456–463 (2013). (19) L. Yu, C. Li, J. Xu, J. Hao, and D. Sun, Highly stable concentrated nanoemulsions by the phase inver- sion composition method at elevated temperature, Langmuir, 28, 14547–14552 (2012). (20) S. S. L im, M. Y. Baik, E. A. Decker, L. Henson, L. Michael Popplewell, D. J. McClements, and S. J. Choi, Stabilization of orange oil-in-water emulsions: a new role for ester gum as an Ostwald ripening inhibitor, Food Chem., 128, 1023–1028 (2011). (21) T. G. M ason, J. N. Wilking, K. Meleson, C. B. Chang, and S. M. Graves, Nanoemulsions: formation, structure, and physical properties, J. Phys. Condens. Matter, 18, R635–R666 (2006). (22) C. Qian and D. J. McClements, Formation of nanoemulsions stabilized by model food-grade emulsifi ers using high-pressure homogenization: factors affecting particle size, Food Hydrocoll., 25, 1000–1008 (2011). (23) K. Rahn -Chique, A. M. Puertas, M. S. Romero-Cano, C. Rojas, and G. Urbina-Villalba, Nanoemulsion stability: experimental evaluation of the fl occulation rate from turbidity measurements, Adv. Colloid. Interface Sci., 178, 1–20 (2012). (24) K. Rahn -Chique, A. M. Puertas, M. S. Romero-Cano, C. Rojas, and G. Urbina-Villalba, Nanoemulsion stability: experimental evaluation of the fl occulation rate from turbidity measurements, Adv. Colloid. Interface Sci., 178, 1–20 (2012). (25) A. Ali, N. Akhtar, and F. Chowdhary, Enhancement of human skin facial revitalization by moringa leaf extract cream, Postep. Dermatologii i Alergol, 31, 71–76 (2014). (26) M. Chie sa, J. Garg, Y. T. Kang, and G. Chen, Thermal conductivity and viscosity of water-in-oil nano- emulsions, Colloids Surf. A Physicochem. Eng. Asp., 326, 67–72 (2008).

GLUTATHIONE-LOADED NANOEMULSION 267 (27) D. S. B ernardi, T. A. Pereira, N. R. Maciel, J. Bortoloto, G. S. Viera, G. C. Oliveira, and P. A. Rocha-Filho, Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assess- ments, J. Nanobiotech., 9, 44 (2011). (28) R. P. P atel and J. R. Joshi, An overview on nanoemulsion: a novel approach, Int. J. Pharm. Sci. Res., 3, 4640–4650 (2012). (29) S. Kott a, A. W. Khan, S. H. Ansari, R. K. Sharma, and J. Ali, Formulation of nanoemulsion: a comparison between phase inversion composition method and high-pressure homogenization method, Drug Deliv., 7544, 1–12 (2013). (30) S. Hona ry and F. Zahir, Effect of zeta potential on the properties of nano-drug delivery systems—a review (Part 1), Trop. J. Pharm. Res., 12, 255–264 (2013). (31) E. A. O strosky, P. A. Rocha-fi lho, and L. M. Veríssimo, Production and characterization of cosmetic nanoemulsions containing Opuntia fi cus-indica (L.) mill extract as moisturizing agent, Molecules, 20, 2492–509 (2015). (32) L. Goehr ing and C. Bahr, Interfacial mechanisms in active emulsions, Soft Matter, 10, 7008–7022 (2014). (33) P. S. Cl egg, J. W. Tavacoli, and P. J. Wilde, Soft matter one-step production of multiple emulsions, Soft Matter, 12, 998–1008 (2016). (34) A. Manda l, A. Bera, K. Ojha, and T. Kumar, Characterization of surfactant stabilized nanoemulsion and its use in enhanced oil recovery. SPE Int. Oilf. Nanotechnol. Conf., 6, 80–92 (2012).