99 Peptide Effects on Photoaging This study investigated the reasons for the loss of follow-up, which were all due to busy work schedules. The dropout rate was higher in the treatment group compared with the control group, which may also lead to the deviation of the results in the treatment group. In addition, during this study, only 2 subjects experienced symptoms of dryness, mild erythema, and mild scaling at week 2, which were resolved spontaneously after one week, possibly due to seasonal changes in windiness and decreased humidity. Therefore, it was found that the peptide complex cream was safe to use and tolerable for subjects. CONCLUSIONS The current study demonstrated that the peptide complex cream containing carnosine, palmitoyl pentapeptide-4, and acetyl hexapeptide-8 can improve partial photoaging symptoms of the face, and it is a safe and tolerable treatment for skin photoaging. This study revealed for the first time the unique efficacy of the peptide complex cream in improving acne, which may be more extensively investigated in future studies. The effect of the peptide complex cream on wrinkles and color spots needs to be further studied by increasing the research time and sample size. AUTHOR CONTRIBUTIONS Qiao Tang and Wenting Cao contributed equally to this article and are co-first authors. This study was planned and designed by Danqi Deng, Jiehao Qian, Wenfang Wang and Wenting Cao. Jichun Yang contributed to study design. Qiao Tang contributed to data collection and data analysis. Qiao Tang and Jiehao Qian drafted this paper. All authors critically revised this paper and approved the final version to be published. The order of the co-first authors was determined based on the extent and duration of the work each contributed to the project. FUNDING STATEMENT This work was supported by the Funded by the National Natural Science Foundation of China (81960568). Experimental products Funded by Zhuhai Yasha Biotechnology Co., Ltd. ACKNOWLEDGMENTS We would like to express our sincere gratitude to Zhuhai Yasha Biotechnology Co., Ltd. for providing the experimental products. We would also like to acknowledge the Dermatology and Venereology Team of the Second Affiliated Hospital of Kunming Medical University in recruiting patients. There are no conflicts of interest or financial disclosures. ETHICAL STATEMENTS The study was approved by the Ethics Committee of the Second Affiliated Hospital of Kunming Medical University (S-PJ-2020-147) and registered on the Chinese Clinical Trial Registry (ChiCTR2100042842).

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