USE IN COSMETICS OF FURYLGLYCINE 77 REFERENCES (1) Minor, V., ?erh. l. Internat. Neur. Kongr., 341 (1932) Zblt. Haut u. Geschl., 44, 727 (1933) (2) Manuila,L., Dermatologica, 100, 304 (1950). (3) Manuila, L., and Islet, H., Ibid., 102, 302 (1951). (4) Brun, R., and Manuila, L., Ibid., 104, 267 (1952). (5) Brun, R., and Grasset, N., Ibid., 112, 357 (1956). (6) Brun, R, and Fayre, F., Ibid., 108, 257 (1954). (7) Brun, R., and Domine, E., Atcta Dermato-F'enereol., 38, 91 (1958). (8) Brun, R., and Hunziker, N., Dermatologica, 110, 245 (1955). (9) Brun, R., and N. Hunziker, Ibid., 114, 177 (1957). THE USE IN COSMETICS OF A NEW SYNTHETIC AMINO ACID: FURYLGLYCINE By B. Cocc^, P. RovEsT and G. Presented September 10, 1958, International Symposium, Milan, Italy RECE•TI•¾ (1) wE REPORTEl) on the action of three new synthetic amino acids: d/-1-amino cyclohexane carboxylic acid, d/-1-amino 3- methyl carboxylic acid and d/-1-amino cyclopentane carboxylic acid. The results obtained have induced us to continue further studies in this field. This time we have kept in mind the economic factor which plays an important part in our industry. The studies have been directed toward the synthesis of an amino acid, furylglycine, whose basic material, furfural, is economically produced. Furfural is easily obtained from a variety of waste products, such as bran, straw, olive husks, wild plants, etc. On the other hahd, the chemical structure of furylglycine is of particular interest because there is a heterocyclic nucleus with a lipophilic charac- teristic linked to the amino and carboxylic functions (which are definitely hydrophilic). We have also studied the action on the skin of the intermediate product in the synthesis of furylglycine (I), that is 5-furylhydantoin (II). I II Quite a number of research workers having observed the close relation- ship between hydantoins and alpha amino acids, have suggested that hydantoic acids and hydantoins might be present in proteins. * Piazza Amendola 1, Milan, Italy. Instituto di Ricerche su Derivati Vegetali, Milan, Italy.

USE IN COSMETICS OF FURYLGLYCINE 77 REFERENCES (1) Minor, V., ?erh. l. Internat. Neur. Kongr., 341 (1932) Zblt. Haut u. Geschl., 44, 727 (1933) (2) Manuila,L., Dermatologica, 100, 304 (1950). (3) Manuila, L., and Islet, H., Ibid., 102, 302 (1951). (4) Brun, R., and Manuila, L., Ibid., 104, 267 (1952). (5) Brun, R., and Grasset, N., Ibid., 112, 357 (1956). (6) Brun, R, and Fayre, F., Ibid., 108, 257 (1954). (7) Brun, R., and Domine, E., Atcta Dermato-F'enereol., 38, 91 (1958). (8) Brun, R., and Hunziker, N., Dermatologica, 110, 245 (1955). (9) Brun, R., and N. Hunziker, Ibid., 114, 177 (1957). THE USE IN COSMETICS OF A NEW SYNTHETIC AMINO ACID: FURYLGLYCINE By B. Cocc^, P. RovEsT and G. Presented September 10, 1958, International Symposium, Milan, Italy RECE•TI•¾ (1) wE REPORTEl) on the action of three new synthetic amino acids: d/-1-amino cyclohexane carboxylic acid, d/-1-amino 3- methyl carboxylic acid and d/-1-amino cyclopentane carboxylic acid. The results obtained have induced us to continue further studies in this field. This time we have kept in mind the economic factor which plays an important part in our industry. The studies have been directed toward the synthesis of an amino acid, furylglycine, whose basic material, furfural, is economically produced. Furfural is easily obtained from a variety of waste products, such as bran, straw, olive husks, wild plants, etc. On the other hahd, the chemical structure of furylglycine is of particular interest because there is a heterocyclic nucleus with a lipophilic charac- teristic linked to the amino and carboxylic functions (which are definitely hydrophilic). We have also studied the action on the skin of the intermediate product in the synthesis of furylglycine (I), that is 5-furylhydantoin (II). I II Quite a number of research workers having observed the close relation- ship between hydantoins and alpha amino acids, have suggested that hydantoic acids and hydantoins might be present in proteins. * Piazza Amendola 1, Milan, Italy. Instituto di Ricerche su Derivati Vegetali, Milan, Italy.