PHOTOCHEMISTRY OF SUNSCREENS 269 ZUSAMMENFASSUNG Isolierung und Identifizierung zweier weiterer Photoreaktionsprodukte des Methyl-p-dimethylaminobenzoats werden beschrieben. Die Ultraviolett- bestrahlung dieset Verbindung in 1,4-Dioxan in Gegenwart yon Sauerstoff lief eft auch Methyl-p-N-formylaminobenzoat und Methyl-p-aminobenzoat. Die Isolierung erfolgte gas-chromatographisch. Beide Produkte wurden dutch Vergleich der IR-, NMR- und Massenspektren der isolierten und synthetisier- ten Substanzen identifiziert. FOr das in einer friiheren Mitteilung behandelte Methyl-p-(N-formyl-N-methyl)-aminobenzoat wird eine neue Synthese an- gegeben. LITEKATUK (1) ten Berge, C. D. M., Bruins, C. H. P., und Faber, J. S., ]. Soc. Cosmet. Chemists 23, 289 (1972). (2) Reisch, J., und Niemeyer, D. H., Arch. Pbarmaz. 305, 135 (1972). (3) Moffat, J., Newton, M. V., and Papenmeler, G. J., ]. org. Chemistry 27, 4058 (1962). Wir danken Herrn Prof. Dr. J. S. Faber herzlich ffir die Diskusslon dleser Arbelt, Herrn A. Kiewiet far die Aufnahmen der Massen- und NMR-Spektren, I-Ierrn W. Prummel fiir das Zelchnen der Abbildungen und Friiulein R. Kuiper ffir die KelnschrlPe des Typoskrlptes.

I. Soc. Cosmet. Chem., 25, 271-281 (May 1974) Current Perspectives on Aerosol Toxicity CHARLES O'CONNOR WARD, Ph.D.* Presented May 4, 1973, Seminar, Cincinnati, Ohio Synopsis-The TOXICITY of cosmetic, household, or personal product AEROSOLS is primarily the result of either deliberate abuse or allergic reactions to one or more of the ingredients. Hair sprays, antiperspirants, deodorants, and feminine hygiene sprays, among others, have been reported to produce toxic reactions in some users. A review of the pub- lished experimental and clinical data does not substantiate the contention that, when used as directed, they are hazardous. It is true, for instance, that the fiuorocarbon PROPEL- LANTS, in experimental situations, can sensitize the myocardium to catecholamine-in- duced arrhythmias and thus produce a situation detrimental to the user, but not in the amounts to which the consumer is ordinarily exposed. The differences between toxicity, the inherent ability to produce undesirable alterations in biological tissue, and HAZARD, the likelihood that toxicity will occur, may explain the case for aerosol products. The potential for toxicity of properly packaged cosmetic, household, and personal product aerosols is present the hazard is small under conditions of normal use. INTRODUCTION As with any other type of packaging or delivery system for cosmetics, drugs, or household products, aerosols have characteristics that are uniquely their own. In general, they are safe, convenient, easy to manipulate, and, for the most part, economical to use. In addition to these advantages, however, this particular method of packaging and delivery is somewhat harder to con- trol once the contents have been liberated from the container. Foams, paints, and cosmetic powders are easily seen and handled but many drug and liquid cosmetic formulations, such as deodorants and hair sprays, are hard to see once released and often the respect that other aerosol products are given by the consumer is not accorded these items. Individuals often have a difficult time relating to a substance that, because of its small particle size, is difficult to see thus, the potential hazards, includ- ing warning labels, are often ignored. This can be illustrated in the case of a *St. John's University, College of Pharmacy and Allied Health Professions, Jamaica, N.Y. 11439. 271