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J'. Soc. Cosmet. Chem., 25, 283-296 (May 1974) Testing for Inhalation Toxicity WILLIAM R. TROY, M.S.* Presented March 7, 1973, before the New York Chapter, Clifton, N.I. Synopsis-The purpose of this review is to outline some of the fundamental considerations involved in testing for INHALATION SAFETY of COSMETIC PRODUCTS. Apart from design of the exposure system and selection of test animals, factors such as environmental controls, proper dose levels, and signs of TOXICITY to watch for are of prime importance when conducting such studies. A discussion of three areas of concern with regard to the inhalation safety of cosmetic AEROSOLS is also included. The questions of hair spray "storage disease," possible aspi- ration of spray talc, and allegations of cardiotoxicity of aerosol propellants are treated with regard to experimental activity in these areas and what, if anything, has been proven to date by these investigations. INTRODUCTION Investigations in inhalation toxicity present some rather unique problems. Unlike most other cosmetic products, aerosols are afforded practically immedi- ate access to the systemic circulation by virtue of their being inhaled into the highly vascular lungs. For this reason, the potential for toxicity for such prod- ucts is greater than for formulations that are routinely applied to the skin such as flowing make-ups or body lotions. In addition to the possibility of sys- temic toxicity, there may also be localized adverse effects on the organs of the respiratory system by inhaled toxicants. Naturally, not even the slightest hint of either type of adverse effect would be acceptable for any cosmetic aerosol. The following review has a twofold intention: first, to outline some of the equipment used in inhalation toxicology, parameters measured, and conditions necessary for proper investigation and second, a discussion of the recent literature in the area of cosmetic aerosol toxicology. *Avon Products, Inc., Suffern, N.Y. 10901. 283