294 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS periments (i.e., 10.0%) is about 100 times higher than the total amount of P-12 available in such a can when discharged into an 8 x 8 x 8-foot room, and the effective level of P-11 is at least 10 times that available. Use conditions for this aerosol deodorant would mean about 10-15 see (at most) of propellant discharge, producing a 0.005% concentration of P-12 in this room. Multiple use of several different aerosol products would not even begin to generate propel- lant levels such as are necessary for, or even close to, producing cardiac arrhythmias. It has been known for more than 60 years that halogenated hydrocarbons, such as chloroform, are capable of sensitizing the heart to epinephrine. Origi- nally intended for use as refrigerants, and then utilized in aerosol devices, the fiuorinated hydrocarbons were carefully tested for their toxic effects after inhalation of concentrations that were thought to be far in excess of any pos- sible perversions of use. As it turns out, however, it was not contemplated that they would be sprayed into a bag and then inhaled at a concentration of up- wards of 80%. Abuse of this type is impossible to control and diffleult to pre- vent. However, it must be kept in mind that this is an unintended misuse of the product, practiced by an extremely small percentage of the people who use aerosols. Fortunately, it appears that this fad may have run its course (or that the word may have spread about the inherent dangers), because the fre- quency of reports in the literature has declined greatly since the peak in 1969-71. We must admit, then, that as our aerosol products are made today, there is a possibility for abuse. However, there is absolutely no evidence yet to show that the fiuor:nated hydrocarbon propellants, at levels that would be encoun- tered during normal, or even exaggerated, use, have any deleterious effects on the user of a cosmetic aerosol. The cosmetic industry, fi•rough the CTFA and CSMA, has taken a very responsible position on the issue of propellant tox!eity anti has commissioned several studies into the effects of these propel- lants on both animals and humans. In addition, they have instituted an educa- tional program in which school-age children are shown a film dealing with the dangers in propellant abuse. While the last word has yet to be spoken on the ultimate safety of fi•e aero- sol propellants, this author hopes that when it is, it will be based on scientific evidence and n,•t on purely emotional considerations. The difference between conditions of use and those of gross abuse are great, and must be taken into account when any statements are made about propellant safety. (Received July 11, 1973 ) REFERENCES (1) Vogin, E. E., Goldhamer, R. E., Scheimberg, J., and Carson, S., Teratology studies in rats and rabbits exposed to an isoproterenol aerosol, Toxicol. Appl. Pharmacol., 16, 374-81 (1970).

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