SKIN AND IMMUNITY 2 5 7 dermal thymocyte-activity factor (ETAF) synthesis by the keratinocyte or LC. Studies show that IL-1 (ETAF-Iike) causes a sharp increase in production of PGE 2 (18). REFERENCES (1) W. E. Parish, "Clinical Immunology and Allergy," in R. Fitzpatrick, Dermatology, Chapter 10. (2) J. D. Bos, The skin immune system, Immunol. Toady, 7, 235 (1986). (3) P. R. Bergstresser, Immunology and skin disorders, Drug Develop. Res., 13, 107 (1988). (4) K. A. Smith, Interleukin-2, Sci. Amer., March 1990, p. 50. (5) D. N. Sauder et al., UV radiation inhibits alloantigen presentation by epidermal cell, J. Invest. Dermatol., 80, 485 (1983). (6) J. W. Streilein and P. R. Bergstresser, Langerhans cells: Antigen presenting cells of the epidermis, Immunobiol., 168, 285 (1984). (7) J. W. Streilein, Skin-associated lymphold tissues (SALT),J. Invest. Dermatd., 80, 125-165 (1983). (8) J. W. Streilein et al., Depletion of epidermal Langerhans cells and Ia immunogenicity from tape- stripped mouse skin, J. Exp. Med., 155, 863 (1982). (9) L. A. Rheins, Induction of Thy-1 antigenic markers on keratinocytes and epidermal immune cells following topical treatment with preservatives, J. Invest. Dermatol., 89, 489 (1987). (10) E. Tschachler et al., Expression of Thy- 1 antigen by murine epidermal cells, J. Invest. Dermatol., 81, 282 (1983). (1 l) P. R. Bergstresser et al., Thy-1 antigen-bearing dendritic cells populate murine epidermis,J. Invest. Dermatol., 81, 286 (1983). (12) C. A. Dinarello, An update on human interleukin, J. Clin. Immunol. 5, 287 (1985). (13) D. N. Sauder et al., Epidermal cell production of thymocyte activating factor (ETAF), J. Invest. Dermatol., 79, 34 (1982). (14) B. A. Gilchrest and D. N. Sauder, Autocrine growth stimulation of human keratinocytes by ETAF, Clin. Res., 32, 585A (1984). (15) L. A. Rheins et al., Alpha-melanocyte stimulating hormone modulates contact hypersensitivity re- sponses, J. Invest. Dermatol., 93, 5 ! 1 (1989). (16) J. G. Nicolas et al., Epidermal cell-derived lymphocyte differentiating factor (ELDIF), J. Invest. Dermatol., 88, 161 (1987). (17) L. A. Rheins et al., The role ofantioxidants in skin immune reactions, J. Soc. Cosmet. Chem., 40, 101 (1989). (18) L. A. Rheins, Suppression of cutaneous immune response following topical application of prosta- glandin PGE2, Cellular Iraround., 106, 33 (1987). (19) L. A. Rheins et al., Modulation of epidermal Langerhans cells associated with cutaneous immune reactivity, J. Immunol., 136, 867 (1986). (20) S. Amornsiripanitch et al., Immune studies in depigmenting mice,J. Immunol., 140, 3438 (1988).
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