MICBOBIAL QUALITY CONTBOL 79 Figure 3. Highly efficient microporous filter mounted onto air inlet of kettle cover and mouth mask. Their shoes must be changed and their hands disinfected with chlorhexidine in 70 per cent alcoholic solution. Only healthy working personnel are selected, and they are required to have periodic health checkups. After proper indoctrination with regard to the purpose for man- ufacturing this particular type of cosmetic, they are instructed in the funda- mentals of preventing microbial contamination. Figure 6 illustrates these uniforms. Countermeasure for Preventing Microbial Contamination of Container In order to avoid any contamination during distribution and also. to impede to the utmost any other secondary contamination, the container has an unique packaging structure. The collapsible tubes are small in size with closed nozzles. To open the nozzles, the loose blue ring at the base of the cap is removed, and the tube is pierced by the sharp protrusion on the inner side of the cap when the cap is screwed down completely. This is seen in Fig. 7. Upon delivery only a few microbial cells were found in the tubes, which is quite a low degree of contamination however, the tubes are sterilized to
80 JOUBNAL OF THE SOCIETY OF COSMETIC CHEMISTS ß . '•! '•" '.. ß .... ...... ii• .... 'i:"•'?::"• 7•i ........... •'• ....... '•:•' " "•?::•? •*':•: •:' "•:"•" ?*i:: t' '• ...... -'• ........... •'• ..... . .... ::•.• . . ?. -----•... --• . .' . ...7:7 :..:• :::j•: ...•. ':•: ....... v•$: ....• ..v:..:.:.... ß -•'. .• ...• •......:•: . ..::•.., ]::.::•.:'•:•.:..:.::.:.. :.• '• :.•:• •.•:7::. •'...:.::' -•-"'"•¾•'" . '•'• •: .%.• .-. '• .. •::: •' ?:':?: •?.... .• : ..: ' •.... :.....:.•/:::•. '" :..: (• r.'• :• %::: •.•: •..:•.: .• ...:/:•.:. ?. :. :.•j• .?:•:•..•:4•%:• •:?'•i•,,'•i :'•.:• •:: •?•-•:•?¾: ::.½•.:.: •e•?•:•'•j•4:•4z•:•.•E.•F::•::?:",::]4•::::•3•'•'•w•':? ß .• .•..•.•:,j:•:.•:.:•::•:4::3 :• ß •:•.•v•t•:•::::...?:•::jj:.•.:.:.•U:•?....:•:•....•.•32:v Figure 4. View of alcan room Dom an•ranea. Translation of Japanese si• in pie•a: Caudon, when an[aring the alcan r•m, [•e [he fo•ow•g preeau[ions: (1) wear duse-free garments complete wi• head cover and mouth mask (•) •ake air shower •d (3) disinf• hands wi•h •1orhexidina soludon Packaging materials Working )ersonnel / EmergencexitDoor Door Auto-door Pass boxx tall , ' ...... ,////•- -. •• ............... ]/l ....... ,% .......... J L A• S•ow.• I I1• ' .•,•.ow. •, _ [• / ,•[•hou•t grill o ( I o,.o ............... ( .................................... ..............l I ..... ..... ]Blower Wash area Window Prefilter Storage tank .bsc lute filter Filling machines E•guve •. Layou[ of clean room
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