NITROSAMINE ANALYSIS 251 NDE1A AREA INJECTION POINT 1 Figure 5. HPLC of a sunscreen lotion showing separation of NDE1A. J NDE1A AREA INJECTION POINT Figure 6. HPLC of reinjected sample collected from a sunscreen lotion.
252 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS the LC method is accurate, reproducible, and reliable for routine analysis. Our work has shown the UV detector is very sensitive and stable for quantitating nitrosamines. REFERENCES (1) J. M. Barnes and P. N. Magee, Br.J. Ind. Med. 11,167-74 (1954). (2) P. N. Magee andJ. M. Barnes, Br.J. Cancer, 10, 114-22 (1956). (3) H. Druckery, R. Preussman, S. Ivankovic, and D. Schmahl, Z. Krebsforsch. Klin. Onkol. 69, 103-201 (1967). (4) M. L. Douglass, B. L. Kobacoff, G. A. Anderson, and M. C. Cheng, J. Soc. Cosmet. Chem. 29, 581-606 (1978). (5) T. Y. Fan, J. Morrison, D. P. Rounbehler, R. Ross, and D. H. Fine, Science, 196, 70 (1977). (6) L. K. Keefer and P. O. Roller, Science, 181, 1245 (1973). (7) T. Y. Fan, U. Goff, L. Song, D. H. Fine, G. P. Arsenault, and K. Biemann, Food Cosmet. Toxicol. 15, 423-430 (1977). (8) I. Schmeltz and A. Wenget, Food Cosmet. Toxicol. 17, 105-109 (1979). (9) N-nitroso Compound Analysis and Formation, IARC Scientific Publication' No. 14 International Agency for Research on Cancer, Lyon, France (1972). (10) P. Rahn and W. Mitchell, Drug Cosmet. Ind., 123 (5), 56-66, 126, & 130 (1978). (11) I.E. Rosenberg, J. Gross, T. Spears, and U. Caterbone,J. Soc. Cosmet. Chem., 30, 127-135 (1979). (12) Federal Register, 44 (70)21365-21367, April 10, 1979.
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