300 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Figure la. The same panelist's right flex area that was washed nine times with bar B. This flex exhibits an irritation score of 2. 3. A survival test was conducted on the number of washes a site was exposed to prior to termination. RESULTS Irritation due to the use of the test material develops over the five-day test period. The clinical appearance of the flex area undergoing repeated washing with a cleansing bar

METHOD FOR SKIN IRRITATION 301 Figure lb. A panelist's left flex area that has been washed nine times with bar A. No indication of irritation exists. ranges from normal (Grade 0), to deep erythema with edema (Grade 3). A score of Grade 2 is the termination point in the flex wash test due to panelist discomfort. A characteristic response for Grade 0 and Grade 2 is shown in Figure 1. The skin's response to the treatment increases at different rates depending on the rela- tive irritancy potential of the bar. Table II provides a summary of four studies com- paring bars with varying degrees of relative irritancy potential. The increase in mean

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