]. Cosmet. Sci.J 57, 259-260 (May/June 2006) Abstracts Journal of the Society of Cosmetic Chemists Japan Vol. 40, No. 1, 2006* A Study on Neck Skin Physiology and Its Application to value between the cheek (heavily sun-exposed area) and Development of Cosmetics back (not sun-exposed area) . From these results it was considered that not only intrinsic aging but also Naomi Kunizawa•2, Yuji Masuda•2, Keiko Takada•3, photo-aging affected the neck skin. We developed the Shinji Inomata•3, Mutsuko Oki•4, Takayuki Oomura•4, prototype of cosmetics corresponding to neck skin Takanari Tsuda•4, Motoji Takahashi•2 physiology based on these results, and evaluated the effectiveness of the prototype product by a consumer test Shiseido Life Science Research Center•2, 2-2-1, including skin measurement for 4 weeks. After treatment, Hayabuchi, Tsuzuki-ku, Yokohama 224-8558, Japan - water content increased, and it gave satisfaction in the skin Shiseido l\1aterial Science Research Center+3, 2-2-1, color brightness, skin elasticity and skin texture Hayabuchi, Tsuzuki-ku, Yokohama 224-8558, Japan - improvements for almost all volunteers. It was concluded Shiseido Product Development Center+4, 2-2-1, Hayabuchi, that the prototype product was useful in neck skin Tsuzuki-ku, Yokohama 224-8558, Japan treatment. The neck is a sun-exposed area. It seems to show the symptoms of photo-aging as well as facial skin in the Material Design Using Genetic Algorithms and Preparation elderly. However, the physiological study of neck skin has oflnnovative lN-Reflecting Composite hardly been reported. We examined the change of skin physiological properties at a neck site with aging for 61 Ryuichi Inaba, Kazuhisa Takahashi, Shigenori Kumagai women (18 to 69 years old) compared with a cheek site. Water content in stratum corneum (SC) was higher, TEWL Nippon Shikizai, Inc., 5-3-13, Mita, Minato-ku, Tokyo was lower and the turnover rate of SC judged from 108-0073, Japan comeocyte area was slower at the neck site compared with the cheek site. Skin thickness was thinner, skin extensibility Genetic algorithm (GA) , which is one of the methods that and elasticity were higher, skin grooves were deeper, and optimize the combination of facton., was applied to the anisotropy of skin furrows was lower at the neck site than design of a new cosmetic material. GA effectively gives an those at the cheek site. It was shown that the neck was also adequate solution especially when there are huge facton. affected by sunlight but not so much as the cheek from the and infinite combinations among those individual factors. result of gelatinase activity detected in the tape stripped SC. In this work, the lN-Reflecting composite that effectively Skin elasticity decreased with aging at the neck site as well reflects lN light and has high visible light transparency as the cheek site. Fine wrinkles were remarkably increased was chosen as the target material. From GA simulation, a in the direction of Langer's line with aging at the neck. blueprint of the composite was obtained as follows: The Most skin physiological parameten. at the neck showed the multiple la yen. on the core material (mica) should be 27 nm * These abstracts appear as they were originally published. They have not been edited by the Journal of Cosmetic Science. 259

260 JOURNAL OF COSMETIC SCIENCE titanium dioxide, 42 nm silica, 33 nm titanium dioxide, and atopic disposition has a significant difference compared to 115 nm silica (from the inner layer) . According to the that of the other subjects in December. Furthermore, it was results, the composite was prepared, and its cosmetic shown that change of APAc in the children under medical properties were evaluated. This composite showed both treatment was correlated with clinical findings. In high lN reflection effect and good visible light conclusion, it was thought that the APAc shown as the transparency while having a smooth feeling on use, index of skin barrier dysfunction is associated with the compared with the commercial ultra fine titanium dioxide. onset age of atopic dermatitis in childhood. Relationship between the Average Projected Area of From Age of Fast Beauty to Age of Slow Beauty, the Comeocytes and the Onset Age of Atopic Dermatitis in Post-Modem Value Childhood Kaori Ishida Satoshi Hirakawa•2, Naoko Ota•2, Masayuki Shimaoka•3, Woo Man•3, Kazuya Yamamoto•4 Komazawa Women's University, 238, Sakahama, Inagi 206-8511, Japan Shiseido Co., Ltd., 3-9-1, Nishigotanda, Quality Design & Assurance R&D Department, POLA Shinagawa-ku, Tokyo 141-0031, Japan Chemical Industries, Inc. •2, 560, Kashio-cho, Totsuka-ku, Yokohama 244-0812, Japan - Shimaoka Hospitat•3, Cosmetic behavior, in which there are make-up, skin care, 68,Karahashi-hiragaki-cho, Minami-ku, Kyoto 601-8469, body painting, bath, shampoo, tooth brushing, combing, Japan - Department of Dermatology, Aiiku Hospitat•4, 5-6-8,Minami-Azabu, Minato-ku, Tokyo 106-8580, Japan haircut, nail care and so on, historically has never broken off. And it is a fact that there is no race in the earth which doesn't have cosmetic behavior. Cosmetic behavior has In childhood, atopic dermatitis typically begins around 2 to universality in time and space. Human beings is an animal 6 months of age. It is thought that the skin barrier that can live without cosmetic behavior. What have human dysfunction as well as allergic disease is important in the beings been seeking for in cosmetic behavior? What have mechanism of atopic dermatitis. However, there are few human beings been expressing by it? Through seeing some reports of the skin barrier function in childhood. So we historical episodes of cosmetical behavior, we know that examined the relationship between the longitudinal surveys fast life, which began with modernization, brought us fast of the skin barrier function through the average projected beauty. Fast beauty is standardized beauty, youth is area of comeocytes (APAc) and clinical findings in children indispensable for it. Therefore the immediate effect of from one month to 12 months. As a result of examinations, keeping and seeking youth is requested from cosmetics. APAc of cheek and upper arm in one-month-old children is Opposite to fast beauty I suppose slow beauty as the the same as those in adults, and APAc of cheek and upper standard value in the next social stage. Slow beauty is arm decreases by six months of age. These results suggest that the skin barrier function decreases before or after the onset age of atopic dermatitis during childhood. Moreover, we examined APAc of children aged 0-5 for one year in the same nursery. APAc of upper arm in atopic dermatitis or diversification of beauty value, expressed "beauty of each person and each age." The standard of beauty is not in each person but in each age of oneself Beauty is acquired by everyday accumulation we can realize different beauty with the accumulation of years. This is true aging.