JOURNAL OF COSMETIC SCIENCE 228 (8) K. M azak and B. Noszal, Zwitterions can be predominant in membrane penetration of drugs: experi- mental proof, J. Med. Chem., 55, 6942–6947 (2012). (9) R. J . Huxtable, Physiological actions of taurine, Physiol. Rev., 72, 101–163 (1992). (10) C. Korponyai, R. K. Kovacs, G. Eros, S. Dikstein, and L. Kemeny, Antiirritant properties of polyols and amino acids, Dermatitis, 22, 141–146 (2011). (11) S. Dincer, A. Babul, D. Erdogan, C. Ozogul, and S. L. Dincer, Effect of taurine on wound healing, Amino Acids, 10, 59–71 (1996). (12) D. L. P. da Silva, S. B. Thiago, F. A. Pessoa, Y. Mrestani, H. H. Ruttinger, J. Wohlrab, and R. H. H. Neubert, Penetration profi le of taurine in the human skin and its distribution in skin layers, Pharm. Res., 25, 1846–1850 (2008). (13) C. J. Jong, J. Azuma, and S. Schaffer, Mechanism underlying the antioxidant activity of taurine: preven- tion of mitochondrial oxidant production, Amino Acids, 42, 2223–2232 (2012). (14) B. Vazquez, G. Avila, and B. Escalante, Antiinfl ammatory activity of extracts from Aloe vera gel, J. Ethnopharmacol., 55, 69–75 (1996). (15) J. Reuter, A. Jocher, J. Stump, B. Grossjohann, G. Franke, and C. M. Schempp, Investigation of the anti-infl ammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test, Skin Pharmacol. Physiol., 21, 106–110 (2008). (16) L. T. Fox, M. Gerber, J. L. du Preez, J. du Plessis, and J. H. Hamman, Skin permeation enhancement effects of the gel and whole-leaf materials of Aloe vera, Aloe marlothii and Aloe ferox, J. Pharm. Pharmacol., 67, 96–106 (2015). (17) T. Lebitsa, A. Viljoen, Z. Lu, and J. Hamman, In vitro drug permeation enhancement potential of aloe gel materials, Curr. Drug Deliv. 9, 297–304 (2012). (18) K. A. Todorova and I. P. Pencheva, Analytical approaches and methods in quality control procedures of energy food drinks containing caffeine and taurine. Int. J. Nutr. Food Sci., 4, 1–8 (2015). (19) K. Laden, Antiperspirants and Deodorants, 2nd Ed. (Marcel Dekker, Inc., New York, 1999), pp. 289. (20) T. S. Kupper and R. W. Groves, The interleukin-1 axis and cutaneous infl ammation, J. Invest. Dermatol., 105, 62–66 (1995). (21) L. P. Bernhofer, S. Barkovic, Y. Appa, and K. M. Martin, IL-1α and IL-1ra secretion from epidermal equivalents and the prediction of the irritation potential of mild soap and surfactant-based consumer products, Toxicol. Vitro, 13, 231–239 (1999). (22) T. We lss, D. A. Basketter, and K. R. Schroder, In vitro skin irritation: facts and future. State of the art review of mechanisms and models, Toxicol. Vitro, 18, 231–242 (2004). (23) K. Sh arma, A. Mittal, and N. Chauhan, Aloe vera as penetration enhancer, Int. J. Drug Dev. Res., 7, 31–43 (2015). (24) L. Co le and C. Heard, Skin permeation enhancement potential of Aloe vera and a proposed mechanism of action based upon size exclusion and pull effect, Int. J. Pharm., 333, 10–16 (2007). (25) A. Co povi, O. Diez-Sales, J. V. Herraez-Dominguez, and M. Herraez-Dominguez, Enhancing effects of alpha-hydroxacids on “in vitro” permeation across the human skin of compounds with different lipophi- licity, Int. J. Pharm., 314, 31–36 (2006).