EFFECT OF A UREA-BASED COMPOUNDED MOISTURIZER 213 (17) S. G. Danby, K. Brown, T. Higgs-Bayliss, J. Chittock, L. A lbenali, and M. J. Cork, The effect of an emollient containing urea, ceramide NP, and lactate on skin barrier structure and function in older people with dry skin, Skin Pharmacol. Physiol., 29, 135–147 (2016). (18) Y. Anwar and E. J. Lowenstein, Eucerin: a revolutionary f o rmulation still going strong for over a century, Skinmed, 14(6), 437–439 (2016). (19) S. Ahmad Nasrollahi, A. Ayatollahi, T. Yazdanparast, A. S a madi, H. Hosseini, M. Shamsipour, A. S. Akhlaghi, S. Yadangi, C. Abels, and A. Firooz, Comparison of linoleic acid-containing water-in-oil emulsion with urea-containing water-in-oil emulsion in the treatment of atopic dermatitis: a random- ized clinical trial, Clin. Cosmet. Invest. Dermatol., 11, 21–28 (2018). (20) R. Chang, A. Raw, R. Lionberger, and L. Yul, Generic deve l opment of topical dermatologic products: formulation development, process development, and testing of topical dermatologic products, AAPS J., 15(1), 41–52 (2013). (21) C. Couteau, L. J. M. Coiffard, and V. Sébille-Rivain, Infl uence of excipients on moisturizing effect of urea, Drug Dev. Ind. Pharm., 32(2),239–242 (2006). (22) H. Kim, J. Ro, S. Barua, D. S. Hwang, S. J. Na, and H. S. Lee, Combined skin moisturization of lipo- somal serine incorporated in hydrogels prepared with carbopol ETD 2020, rhesperse RM 100 and hyal- uronic acid, Korean J. Physiol. Pharmacol., 19(6), 543–547 (2015). (23) P. M. Elias, Stratum corneum acidifi cation: how and why? Exp. Dermatol. , 24, 179–180 (2015). (24) P. M. Elias, The how, why and clinical importance of stratum corneum ac i difi cation, Exp. Dermatol., 26, 999–1003 (2017). (25) A. Kilic, C. Masur, H. Reich, U. Knie, D. Dähnhardt, S. Dähnhardt-Pfeif f er, and C. Abels, Skin acidi- fi cation with a water-in-oil emulsion (pH 4) restores disrupted epidermal barrier and improves structure of lipid lamellae in the elderly, J. Dermatol., 46(6), 457–465 (2019). (26) S. G. Danby, J. Chalmers, K. Brown, H. C. Williams, and M. J. Cork. A functional mechanistic study of the effect of emollients on the structure and function of the skin barrier, Br. J. Dermatol., 175(5), 1011–1019 (2016).