354 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS skin and one to certain skin diseases. The initial chapter on "Ultrastruc- ture of Human Epidermis and Hair Follicles" is comprehensive and well presented with excellent il- lustrations. The chapter on"Kera- tinization and Proteins" seems in- complete without some discussion of turnover rates of epidermis or hair. The chapter on "Pigmenta- tion" discusses the chemistry of melanin formation and its hormonal control. The discussion of pig- mentation caused by ultraviolet irradiation focuses on the inflam- matory processes, with scarce men- tion of how pigmentation is medi- ated chemically. The chapter on "Lipid Composi- tion" is mainly an uncritical com- pilation of data. The discussion of control of sebaceous flow is out of date. The chapter on "Enzymes" is poorly organized. It is presented in an historical fashion with later portions contradicting earlier con- clusions. A chapter on "Water, Minerals, pH and Sweat" is well presented, although discussion of sweating and acclimatization is very brief. The chapter on "Connective Tissue" is well done and quite complete. The chapter on "Human Hair" is very superficial in its treatment of the organic chemistry of keratin. A discussion of hair waving curiously focuses mainly on the swelling be- havior of hair in thioglycolate solu- tions. No estimates are given of hair growth rates. The final chap- ter on "Diseases of the Skin" is adequate. The book has the usual number of typographical errors, but in addi- tion, the author's grammatical con- struction is frequently poor (even for a scientific book). The book makes good use of numerous tables to present data concisely. How- ever, frequently the text dwells too much on specific experimental de- tails and uses unexplained symbols or abbreviations. Overall, the prin- cipal value of the book to those interested in cosmetics is the ex- tensive bibliography following each chapter.--PAu•. FINKELSTEIN, The Toni Co. DANGEROUS PROPERTIES OF IN- DUSTRIAL MATERIALS by N. Irving Sax. 2nd Edition, Reinhold Pub- lishing Corp., New York 22, N.Y. 1963. 1232 pages. Price $25. The first 375 pages of this volume are devoted to a description of such diverse subjects as toxicology, venti- lation control, respiratory protec- tion, a•r pollution, radiation hazards, fire protection, storage and handling of hazardous materials, reactor safeguards, allergic diseases, food additives and various shipping regulations. These chapters are di- rected not at experts in these specific areas and should prove helpful to the uninitiated. The chapters on allergic disease and food additives are, of course, interesting to cos- metic chemists. To them, and presumably to all who manufacture or develop consumer products, pages 272 to 275 must come as a serious shock: It is known that, under cer- tain conditions, almost any chemi- cal or finished product can cause contact dermatitis in at least some individuals. On these pages a vari- ety of contact allergens are listed: poison ivy, oranges, peanuts, hand lotion, toothpaste, wool, glycerin, paraphenylenediamine, etc. It is obvious that such a listing is un- warranted because the incidence of allergic disease should have been taken into account. In other words, although an occasional in- dividual may be allergic to tomatoes (which are included in this list), the frequency of allergy to poison ivy is much higher therefore, the two should not be lumped together

JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS 355 in one single tabulation. Despite the obvious shortcomings of the opening chapters, they will be use- ful to those responsible for safety considerations in chemical manu- facturing plants and laboratories. The remainder of the book, al- most 1000 pages, is devoted to the description of the hazard ratings of thousands of individual chemicals. The hazard rating takes into con- sideration local and systemic tox- icity, recommended cautions in handling, etc., fire and explosion hazard and the need for protective clothing, etc., by personnel. A detailed review of these ratings is, of course, impossible. However, a spot check has disclosed no serious errors or omissions, especially with regard to chemicals which are en- countered routinely in the cosmetic and pharmaceutical industry. This reviewer was interested in the toxicity rating of mineral oil and, accordingly, was referred from the entry, mineral oil, on page 1010 to an entry under lard oil on page 926. On the other hand, on page 1081, petrolalum (sic) liquid refers the reader to oil, mineral, which is entered on page 1059. It is interesting to note that the entry under lard oil, pure (•2 mineral oil), differs appreciably from the entry under oil, mineral. Probably a few other inconsistencies and errors have crept into the enormous quan- tity of information compressed into this volume. Thus, an occasional defect of the type cited above does not detract from the value of this book. This volume should be a useful desk reference for every safety director in the chemical and manu- facturingindustry. It should prove equally valuable to laboratory per- sonnel who are constantly using and exposing themselves to a variety of chemicals, the natuye of which is freq•e.n, tl.y not fully..known to them. It is apparent that this volume fulfills a very valuable service. It is hoped that it will receive the wide distribution that it deserves and that it will be consulted fre- quently.--M. M. RIEGER, Warner- Lambert Research Institute. CLINICAL ToxicoLoGY oy COMMER- CIAL PRODUCTS by Marion N. Gleason, Robert E. Gosselin and Harold C. Hodge. 2nd Edition, 1200 q- Pages. The Williams and Wilkins Co., Baltimore, Md. 1963. Price $22. Since the first edition of this volume appeared in 1957, much has happened to make the public more aware of potential hazards resulting from misuse of commercially avail- able chemicals and household prod- ucts. It is no surprise, therefore, that a second edition of this volume was finished sometime during 1962. In contrast to the above reviewed "Dangerous Properties" by Sax, this volume is directed toward physi- cians and others interested in the pre. ven. tion of accidental death from poisoning. Despite emphasis on therapy for poisonings, this volume will interest formulatoTs, chemists and almost all others who, in one form or another, handle chemicals. This volume is divided into eight sections, each of which is color coded. These sections in the order of their appearance are: First Aid and General Emergency Treatment, Ingredients Index, Therapeutic In- dex, Supportive Treatment, Trade- name Index, General Formulations, Manufacturers' Names and Ad- dresses, Classification of Poisons. The first and fourth section are, of course, of primary interest to the clinicJan and are of limited interest to the chemical industry per se. Section •2 is a compilation of in- gredients commonly used in house- hold products. Over 2000 in-