USE OF ANTI-IRRITANTS IN COSMETIC FORMULATING 339 preceding pages. The acid was added at 0.5% to an alcoholic anti- perspirant containing a cationic surfactant its presence increased eye irritation at 0.3%, however, it decreased eye irritation of a cologne by one-third and at 0.5% it reduced primary skin irritation of an O/W protease-containing emulsion. Zirconia Blumenthal (7) states that hydrous and carbonated hydrous zirconia form nonirritating complexes with urushiol, the diphenolic irritating factor of poison ivy. This diphenol may also be detoxified by binding with anion exchange resins of the polystyrene quaternary amine type (8). The author wishes to acknowledge the generosity of Bio-Toxicology Laboratories who donated the rabbits used in the study of the antiper- spirant formulation. (Received July 6, 1964) 1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (I2) (13) (14) (15) (16) (17) (18) (19) (20) (21) (22) (23) (24) REFERENCES Shelanski, H. A., U.S. Pat. 2,739,922, Mar. 27, 1956. Drew, H. F., and Voss, J. G., Can. Pat. 639,398, Apr. 3, 1962. Brit. Pat. 880,200, Oct. 18, 1961. Martin, G., Draize, J. H., and Kelley, E. A., Proc. Sci. Sect. Toilet Goods Assoc., 37, 2 (1962). Sutton, M. G., and Reynolds, M. M., U. S..Pat. 2,759,869, Aug. 21, 1956. Jackson, C. R., U.S. Pat. 2,860,084, Nov. 11, 1958. Blumenthal, W. B., J. Soc. Cosmetic Chemists, 4, 69 (1953). Samuelson, O., Ion Exchangers in Analytical Chemistry, John Wiley & Sons, New York, 1953, p. 121. Battista, S. P., and McSweeney, E. S., J. Soc. Cosmetic Chemists, 16,119 (1965). Goldemberg, R. L., Drug $2 Cosmetic Ind., 85,618 (1959). Taylor, E. A., J. Invest. Dermatol., :t7, 69 (1961). Draize, J. H., Derreal Toxicity, in Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, Assoc. Food and Drug Offieials of the U.S., Austin, Texas (1959). Opdyke, D. L. J., The Accommodation Phenomenon. Presented at the U.C.L.A. Con- ference on the Evaluation of Therapeutic Agents and Cosmetics (1962). Mecca, S. B., Proc. Sci. Sect. Toilet Goods Assoc., 31, 1 (1959). Mecca, S. B., Drug Allied Ind., July (1960). Kahan, H., et at., Arch. Pedlar., 74, 57 (1957). Farkas, A., U.S. Pat. 3,103,466, Sept. 10, 1963. Roboz, E., and Haagen-Smit, A. J., J. Am. Chem. Soc., 70, 3248 (1948). Goff, S., and Levenstein, I., J. Soc. Cosmetic Chemists, 15,509 (1964). Goff, S. R., U.S. Pat. 2,950,255, Aug. 23, 1960. Northover, B. J., and Subramanian, G., Brit. J. Pharmacol., 16,163 (1961). Ruemale, T. A., Am. Perruiner, 75, 32, July (1960). Hertz, A., Arzneimittelforschung, 3,253 (1953). Kuchinka, R., Seifen-Oele-Fette- Wachse, 76, 9, 29, 51 (1950).

340 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS (25) (26) (27) (28) (29) (3o) (31) (32) (33) (84) (35) (36) (37) (38) (39) (40) (41) (42) Dvorkovitz, V., Berst, N. W., and Leist, G. G., U.S. Pat. 2,962,448, Nov. 29, 1960. Ganley, O. H., Graessle, O. E., and Robinson, H. J., J. Lab. Clin. Med., 51,709 (1958). Masters, E. J., N.Y. State J. Med., 60, 1934 (1960). Hatschek, R., and Rogicky, J., Chem. Zent., 2, 1718 (1943). Russell, K., and Hoch, S. G., Proc. Sci. Sect. Toilet Goods Assoc., 37, 27 (1962). Maso, H., Private communication ( 1963 ). Nassau, L., J. Am. Oil Chemists' Soc., 37,382 (1960). Steiger, L. W., Proteins for the eye (letter). Chem. Week, 9-16-62. Hoekstra, W. G., and Phillips, P. H., J. Invest., Dermatol., 40, 79 (1963). Rieger, M. M., and Battista, G. W., J. Soc. Cosmetic Chemists, 15,161 (1964). Mannheimer, H., U.S. Pat. 2,773,068, Dec. 4, 1956. Mannheimer, H., U.S. Pat. 2,781,354, Feb. 12, 1957. Guttman. D., and Higuchi, T., J. Am. P harm. Assoc., Sci. Ed., 45,659 (1956). Wilkinson, J. M., et al., C.S.M.A. Proc. (1953). Burnette, L. W., Proc. Sci. Sect. Toilet Goods Assoc., 38, 11 (1962). Prescott, F. J., Hahnel, E., and Day, D., Drug & Cosmetic Ind., 93,443 (1963•. Schimmel Briefs •/295, Oct., 1959. Orentreich, N., Private communication (1962).