556 JOURNAL OF THE SOC1ET¾ OF COSMETIC CHEMISTS : :.•.. ,,:,,-" ½- '5'-', .,•,, •' .•: :•, ,,,,•.' •-• :- '-L .• :.-' • . .•.• •- . •. . ...... . ...... ,..•: . • - ½. ½ :- ............ '•. '=, :"-,• *"-• ,•/'•a,,: - - • , •.. . ½ %•7• • . * *•" "'• :• '• '• • .•' - .... ' .... L• •:"• • '"• :-* ,"½• •" -. ,.:. • -• • %• .... . .... -•½ ,.... . ½ 2..:.½•..• .... •, .,.-: ..... •. •:: .,m .:.: ,.. •. ..- .• - • :,.? - •[: "...•':. . .,•' j:• '•.• :...[ ,•- ..... . .... , .: ..:• • rr• • . .•.• ..... .:.•: :-•. :-.?-..• •. _• ' . , :.,.. .... .•,.. ...... •,.Y' :• •.. ½- -• . , ...5• .-" ..."'-.%:• ,•-.. •-. .... ": ?:¾' :"::':::('I. :'•' .... .'.. ' ::::2. ':•% :• . .., ' :::. e'- .• *• ...... . ::" ' ...' . :":.::•. :•,,•. .•.(::• :::• '•:".• '•2•:-• '•:- :z . x : : .%.. . . . ..•.. • : • ..... :-. -. .-. .•:.&. -• ..' .*½: z-•, • ..}-.•:... ': '. ß .: ':•,. '•. '..y• .......,•.:.. ' -•. .."•:... •' .:. ::•:' • .... (A) ..... "• ..-%-.• ...... ...... (t•) Figure 6. Enhancement of epidermal structure by testostcrone. The control specimen (A) from the face of an 80-year-old white woman typifies the chaotic, atrophic epidermis of exposed aged skin. Some of the dc.gradative dermal changes are also evident The testo- sterone-treated side (B) has undergone remarkable "rejuvenation." Both specimens are photographed at the identical magnification (H & E X400)

EFFECT OF TOPICAL HORMONES ON SKIN 557 Figure 7. Effect of topical tcstosterone on the basement tnetnbrane. The control site (A) from the face of an 80-year-white wotnan shows a much attenuated, discontinuous structure that is barely visible. The hormone treated skin (B) demonstrates a fine, serrated band of PAS positive tnaterial along the length of the dertno-epidermal junction. (Original magni- fication 400X )