80 JOUBNAL OF THE SOCIETY OF COSMETIC CHEMISTS ß . '•! '•" '.. ß .... ...... ii• .... 'i:"•'?::"• 7•i ........... •'• ....... '•:•' " • "•?::•? •*':•: •:' "•:"•" ?*i:: t' '• ...... -'• ........... •'• ..... . .... ::•.• . . ?. -----•... --• . .' . ...7:7 :..:• :::j•: ...•. ':•: ....... v•$: ....• ..v:..:.:.... ß -•'. .• ...• •......:•: . ..::•.., ]::.::•.:'•:•.:..:.::.:.. :.• • '• :.•:• •.•:7::. •'...:.::' -•-"'"•¾•'" . '•'• •: .%.• .-. • '• .. •::: •' ?:':?: •?.... .• : ..: ' •.... :.....:.•/:::•. • '" :..: (• r.'• :• %::: •.•: •..:•.: • .• ...:/:•.:. ?. :. :.•j• .?:•:•..•:4•%:• •:?'•i•,,'•i :'•.:• •:: •?•-•:•?¾: ::.½•.:.: •e•?•:•'•j•4:•4z•:•.•E.•F::•::?:",::]4•::::•3•'•'•w•':? ß .• .•..•.•:,j:•:.•:.:•::•:4::3 :• ß •:•.•v•t•:•::::...?:•::jj:.•.:.:.•U:•?....:•:•....•.•32:v Figure 4. View of alcan room Dom an•ranea. Translation of Japanese si• in pie•a: Caudon, when an[aring the alcan r•m, [•e [he fo•ow•g preeau[ions: (1) wear duse-free garments complete wi• head cover and mouth mask (•) •ake air shower •d (3) disinf• hands wi•h •1orhexidina soludon Packaging materials Working )ersonnel • / EmergencexitDoor Door Auto-door Pass boxx tall , ' ...... ,////•- -. •• ............... ]/l ....... ,% .......... J L A• S•ow.• I I1• ' .•,•.ow. •, _ [• / ,•[•hou•t grill • o ( • I o,.o • ............... ( .................................... ..............l I ..... ..... • ]Blower Wash area Window Prefilter Storage tank .bsc lute filter Filling machines E•guve •. Layou[ of clean room

MICROBIAL QUALITY CONTROL Table V Sterilizing Method for the Filling Equipment 81 Equipment Sterilizing method Storage tank Filling machine Pump Pipes Tools Disinfectant solution (chlorhexidine in 70 per cent alcoholic solution) Disinfectant solution (iodine type) Disinfectant solution (iodine type) Hot water Disinfectant solution (chlorhexidine in 70 per cent alcoholic solution) Figure 6. Working personnel wearing sterile dust-free garments prevent any contamination of the product from this source. Ethylene oxide gas sterilization conditions are the same as those described under cellulose gums. The microbial count found in these tubes is shown in Table IV. The collapsible tubes are received wrapped in a polyethylene protective film and then packaged in corrugated cartons. In this packaged form, the collapsible tubes are sterilized by ethylene oxide gas and subsequently con- veyed in the polyethylene wrapped form through the pass box into the clean room.