548 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Reference has been made above to the use of antibiotics together with esters of p-hydroxybenzoic acid in connection with the stabilisation of vaccines. Another interesting application is the use of these esters together with an antibiotic in the course of antibiotic therapy. Mon. iliasis, an infection by Candida albicans, which arises after continued antibiotic therapy can be successfully treated when using esters of p- hydroxybenzoic acid, referred to in a patent (131). The specification states that with the combined addition of esters of p-hydroxybenzoic acid to preparations containing tetracyclin, undesirable side effects of antibiotic therapy are inhibited. Wegmann (132) has recently confirmed the effective- ness of applying a combined treatment of antibiotics and esters of p- hydroxybenzoic acid in preventing the disturbing side effects resulting from continued antibiotic therapy. (Received: 24th January 1968) (18) (19) (20) (21) {22) (23) (24) (25) (26) (27) REFERENCES (1) Knight, H. T. and Harvey, J. New Zealand Med. J. 68 653 (1964). (2) Anderson, K. Meal. J. Australia 22 463 (1962). (3) Lubsen, N., Boissevain, W. and Fass, H. Lancet (29 April 1961). (4) Kaiser, E., Megay, K. and Pantlitschko, M. Boll. Ist. Sieroterap. Milan, 29 237 (1950). (5) Wedderburn, Doreen L. J. Soc. Cosmetic Chemists 16 395 (1965). (6) Boehm, E. ibid 8 1 (1957). (7) Littlejohn, O. M. and Husa, W. F. J. Am. Pharm. Assoc. Sci. Ed. 44 305 {1955). {8) Warner, M. E. and Gee, A. H. Paper presented at Ann. Meeting of Parenteral Drug Assoc., N.Y., on 27th October 1955. (9) Lawrence, C. A. J. Am. Pharm. Assoc. S•i. Ed. 44 457 (1965). (10) Klein, M., Millwood, E.G. and Walther, W. W. J. Pharm. Pharmacol. 6 725 (1954). (11) Schimmel, J. and Husa, W. J. J. Am. Pharm. Assoc. Sci. Ed. 4õ 204 {1956). (12) Sabalitschka, T. Arzneimittel Forsvh. õ 259 (1955). (la) Pharm. Ztg 108 {1963) 1745 (14) Savin, J. A. Chemist Druggist 187 291 (1967). (15) Brit. Meal. g. 12õ (1967). (16) Burdon, D. W. and Whitby, J. L. Brit. Meal. J. 153 (1967). {17) Tracy, J. M., Glass, D.G., Nicholson, M. J. and Pivnick, H. J. Pharm. Svi. õ8 659 (1964). Pivnick, H., Tracy, J. M., Tosoni, A. L. and Glass, D.G. ibid. 899. Koda, C. F., Grubb, T. C. and Alexander, J. F. ibid. õ4 478 (1965). Waiter, G. R. and Gump, W. S. ibid. õl 707 (1962). yon Moos, R. Schweiz. Apotheker Ztg. 102 194 (1964). Janistyn, H. Parfuem. Kosmetik 40 136 (1959). Clausen, O. G. and Raugstad, K. Norg. Apotekerforen. Tiddskr. 78 365 (1965). Osman, H. G. and el' Maria, h, A. ]. Am. Pharm. Assoc. Sci. Ed. 49 231 {1960). Myddleton, W, W. Mfg. Chemist 81 256 (1960). Gershenfeld, L. Am. Perfumer Cosmetics 78 55 (October 1963). Maccacaro, G. A. Progress and industrial microbiology 8 (1961) (Heywood & Co., London).

SYNERGISM IN VITRO OF CERTAIN ANTIMICROBIAL AGENTS 549 (28) Deeb, E. N. and Boenigk, J. w. J. Am. Pharrn. Assoc. Sci. Ed. 47 807 (1958). {29) Littlejohn, O. M. and Husa, W. F. ibid. 44 305 (1955). (30) Schimmel, J. and Husa, W. J. ibid. 45 204 (1956). {31) U.S. Pat: 2,807,568. (32) Wegmann, T. Deut. Meal. Wochschr. 91 713 (1966).