SEBORRHEIC DERMATITIS Table III Effect of Test Products on Subjective Scalp Itching" 193 Sulfur- Salicylic Acid- Zinc Pyrithione Hexachlorophene Control Shampoo Shampoo Shampoo Average starting grade 0.9 0.7 0.9 Adjusted mean 0.2 b,c 0.5 c 0.5 c (4 weeks) Adjusted mean 0.1 c,• 0.3 b,• 0.5 c (8 weeks) a _ • Numbers of subjects/product/period same as in Table I. 0 Significant product effect, a = 0.05 compared to control. c Significant product effect, a = 0.05 compared to initial grade. a Relative to initial grade. ' Significant product effect, a = 0.05 compared to control and compared to the sulfur- salicylic acid-hexachlorophene shampoo. better than the placebo in which a good or excellent result is seen in only 29% of subjects. Evaluation of oiliness turned out to be not very rewarding and the data are, therefore, not presented here. None of the products had a significant effect on scalp oiliness. However, the two therapeutic sham- poos did show a small directional effect toward reducing the level of scalp oil over that seen with the control product. The subjective itching data (Table lII) indicate that while the use of all three shampoos lowered the awareness of itching, the zinc pyrithione shampoo users reported significantly less subjective itching than did the users of the sulfur-salicylic acid-hexachlorophene shampoo or the control shampoo after 8 weeks' use. CONCLUSIONS Both zinc pyrithione in a shampoo vehicle and a combination of sul- fur, salicylic acid, and hexachlorophene in a shampoo vehicle were effec- tive in controlling seborrheic dermatitis. The zinc pyrithione shampoo was more effective than the shampoo containing the combination of sul- fur, salicylic acid, and hexachlorophene in reducing the seborrheic der- matiris and accompanying itching, but showed no long-term advantages in terms of reducing oiliness. (Received August 23, 1971)

194 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS REFERENCES (1) Lubowe, I. I., Over-the-counter antiseborrheic preparations, Cutis, 4, 295-300 (1968). (2) Roth, H. L., Hydrocortisone-salicylic acid therapy of seborrheic dermatitis--a double blind clinical study, Ibid., 4, 721-6 (1968). (3) Derbes, V. J., Seborrheic dermatitis, Ibid., 4, 553-8 (1968). (4) Smith, J. G., Jr., and Vilgor, R. S., Treatment of seborrheic dermatitis, Proc. Sci. Sect. Toilet Goods Ass., 47, 24-5 (1967). (5) Gabrilova, V. M., Selenium disulfide in seborrhea study, Vestn. Derrrtatol. Venerol, 35, 45-9 (1961). (6) Lubowe, I. I., Treatment of scborrhea of the scalp, Skin, 1, 309-11 (1962). (7) Orentreich, N., Taylor, E. H., Berger, R. A. and Auerbach, R., Comparative study of two antidandruff preparations, ]. Pharm. Sci., 58, 1279-80 (] 969).