EVALUATION BY SLIT-LAMP TECHNIQUES 191 Table IV Slit-Lamp Examination of the Iris _ Iritis Grade 1 Slight congestion of iris vessels usually only part of iris involved Grade 9. Mild congestion of iris vessels, all vessels of the iris involved Grade 3 All vessels of the iris moderately congested Grade 4 All vessels of the iris congested and dilated, with very little normal tissue observable d ...½" i•-" . '2' Figure 13. Normal iris of rabbit eye (Grade = 0) The lens represents a critical structure for evaluation since any drug-related pathological change in the lens represents a substantial toxic phenomenon. Lens pathology also was not covered in the original Draize method, but is usually observed as either opacities of the anterior or posterior capsule, cor- tex, and/or some combination of all (Fig. 16). Separate grading scales may be established for each type of observed opacity. As an example of a grading system for lens opacities, Table V shows changes in anterior capsule integrity. The experience in this laboratory has been that the investigator should not integrate numerical values for each parameter into an average score. The data are best represented by calculating the mean scores for each parameter sepa- rately and indicating the incidence. An overall average score as one can cal- culate by the Draize method does not allow the investigator to illustrate or tabulate what ocular pathological change is more prominent. We no longer calculate average scores but present the data as in Table VI.

192 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS ß. --...•' • •:,•:." •::i:iY •i-? ?. :. •...:. :.:,.:..:. i•ii: ' ß .:.•:..:... - ß ' 't:':•:' ..:.•x. .2. . .. •...}:•:•.:•:::•.. •:..... :•:•::. .... •.:.:. •:.. .:•r .•.• . ß ...... :: •.. • •,.: ::.•?' .'• . .. ... ':".... -: -• •fi• • ..... ..: ...g:.:.: :.•:• Figure 14. Iritis (congestion of iridal vessels) of rabbit eye (Grade • 2) Figure 15. Iritis of rabbit eye (Grade -----4). (Note: Hyperfolding-edema)