EVALUATION BY SLIT-LAMP TECHNIQUES 195 Table VII Evaluation of Slit Lamp Disadvantages Cost of equipment Greater time expenditure for examination Advantages Detection and scoring of minute pathologies not possible with macroscopic examination Examination of anterior chamber, lens, vitreous, and retina Greater flexibility in determining degrees of p•thologic changes, i.e., easier to develop concentration response rela- tionships and/or differences between formulations Reduced investigator-to-investigator variabfiity Photographic recording of observations possible during ex- amination An example of the type of data derived with use of the grading scales and slit-lamp examination is presented in Table VI. Three commercially available shampoos were evaluated for ocular irritation potential in rabbit eyes. The data were tabulated to demonstrate the severity (mean scores ) and frequency (incidence) of each ocular parameter. Based on these data, the investigator indicated that Shampoo B had the lowest potential for ocular irritation while Shampoo C had a high potential for ocular damage. In summary (Table VII), although there are disadvantages to the routine use of the slit lamp for examination of experimental animal eyes, we have found the techniques described in this text superior, in most instances, to macroscopic methods. ( Received June 20, 1972) I•EFERENCES (1) Draize, J. H., Woodard, G., and Calvery, H. O., Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes, J. Phar- raacol. Exp. Therap., 82, 377-90 (1944).

596 JOURNAL OF TIlE SOCIETY OF COSMETIC CHEMISTS .Society of Cosmetic Chemists Literature Award to D K j'Ad h' r. en 1 ac 1 The 1972 Cosmetic Chemists Literature Award was presented to Dr. Kcnji Adachi of the University of Miami at the annual meeting held in New York City. Formal presentation was made to Dr. Adachi by Dr. Martin Rieger, the 1972 President of the Society, during the luncheon ceremonies on December 12th. The award consists of a scroll and an honorarium of $1,500. Eulogist for Dr. Adachi was Dr. Bernard Idson of Hoffman-La Roche Inc. Dr. Adachi was honored for his pioneering work in elucidating the enzymatic processes un- derlying the metabolism of skin, sebaceous glands, and hair follicles. Left to right: Society President Martin M. Rieger, Literature Award recipient Kenji Adachi, Mrs. Kenji Adachi, and Eulogist Bernard Idson