212 JOURNAL OF TIlE SOCIETY OF COSMETIC CIIEMISTS (i]•.) (tl3) (114) (115) (116) (117) Dugard, P. II., and Embery, G., The influence of dimethyl sulfoxide on the percu- taneous migration of potassium butyl (•"S) sulphate, potassium methyl (:•"S) sulfate, Brit. ]. Dermatol., 81, Sul pl. 4, 69 (1969). Ramruler, D. H., and Zaffaroni, A., Biological implications of DMSO based on a re- view of its chemical properties. Ann. N.Y. Acad. Sci., 141, 13 (1967). Sweeney, T. M., Downes, A.M., and Matoltsy, A. G., The effect of dimethyl sulL oxide on the epidermal water barrier, I. Invest. Dermatol., 46, 300 (1966). Bettley, F. R., The influence of detergents on epidermal permeability, Brit. J. Derms- tol., 77, 98 (1965). Bettley, F. R., Influence of soap on the permeability of the epidermis, Ibid., 73, 448 (1961). BertIcy, F. R., Irritant effect of soap in relation to epidermal permeability, Ibid., 75, 113 (1963).
Letter to the Editor Emulsion Terminology Sir: I have noted with interest the recent correspondence in your pages (1,2) on the terminology of the aggregated state, particularly with respect to the terminological distinction between "flocculation" and "coagulation." In this respect, I would like to call the attention of your readers to a publi- cation of the Internation Union of Pure and Applied Chemistry (IUPAC) (3) which contains the following paragraphs: "The terms coagulation and lqocculation are often used interchangeably. It has been proposed to introduce a distinction between coagulation, as leading to compact aggregates, and fiocculation, as leading to a loose and open net- work. In view of the more general (but not universal) acceptance of the equivalence of the words coagulation and fiocculation, any author who wishes to use flocculation and coagulation as different notions should clearly state so in his publication... "An emulsion loses its stability in two steps, viz., the formation of aggre- gates (coagulation or ]tocculation) and the flowing together of the original droplets in the aggregates (coalescence). If coalescence is extensive it leads to the formation of a macrophase and the emulsion is said to be breaking. The breaking of a foam may be regarded as coalescence of gas bubbles." The distinction made in the second paragraph quoted is identical with that made by the present writer (4), and this seems to me to be the only pertinent one. Since the distinction between loose and compact aggregates cannot but be a qualitative, subjective one, the distinction has no quantitative force. The important distinction (especially with emulsions) is, of course, between reversibility and irreversibility, and that is the distinction made above. If one wishes to make some sort of (probably unnecessary) distinction between fiocculation and coagulation, it might be well to reserve the latter term to describe the overall process of aggregation, and, in the case of emulsions, use the terms flocculation and coalescence to describe reversible and irreversible aggregation, respectively. PAUL B•C•Ea ICI America Inc. Wilmington, Del. 19899 213
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