JOURNAL OF COSMETIC SCIENCE 56 A/T ratio being a comparison of the number of anagen to telogen hair follicles, the observed increase in A/T ratio attests that the test product is able to promote hair growth in people suffering from recessing hair. CONCLUSION Taken together, these results support the effi cacy of the test product in improving hair growth by rebalancing the A/T ratio and promoting healthy hair growth. The mixture combines the benefi ts of both biochanin A-enriched red clover extract and biomimetic acetyl tetrapeptide-3 to simultaneously address multiple factors involved in the progres- sion of male pattern alopecia. The mixture acts on recessing hair by limiting hormonal infl uence through inhibition of 5-α-reductase activity, preventing aggravation of hair loss due to microinfl ammation and supporting hair growth through stimulation of ECM protein synthesis. Clinical effi cacy in supporting hair growth was successfully addressed in a 4-month randomized, placebo-controlled study involving volunteers presenting signs of male pattern alopecia. Figure 7. Effect of topical application of 20 drops of a 5% mixture of acetyl tetrapeptide-3 and red clover extract (TP) on hair cycle: (A) average anagen hair density at 4 months (T = 4) of treatment, compared to baseline (T = 0) (B) average telogen hair density at 4 months of treatment (T = 4), compared to baseline (T = 0) and (C) average ratio of hair in the anagen versus telogen phase of the hair cycle, at 4 months of treat- ment (T = 4), compared to baseline (T = 0).

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