Table IV Ni MoS Calculation Cosmetic type Maximum detected Ni (μg/g) Maximum %Ni (g) Estimated daily amount applied (g/day) % Dermal absorption SED (mg/kg/day) NOAEL (mg/kg/day) MoS (NOAEL/SED) Mascara 19.02 0.001902 0.025 0.2 1.59 × 10−7 2.2 13,880,126 Eye shadow 9.40 0.000940 0.02 0.2 6.27 × 10−7 2.2 35,106,382 Eyeliner 37.95 0.003795 0.005 0.2 6.33 × 10−7 2.2 34,782,609 Lipstick 4.10 0.000410 0.057 0.2 7.79 × 10−8 2.2 28,241,335 Body lotion NDa NDa 7.82 0.2 NDa 2.2 NDa a Non detectable values were not taken into account for calculation. ALLERGEN METALS IN COSMETICS 319

Table V Cr MoS Calculation Cosmetic type Maximum detected Cr (μg/g) Maximum %Cr (g) Estimated daily amount applied (g/day) % Dermal absorption SED (mg/kg bw/day) NOAEL (mg/kg bw/day) MoS (NOAEL/SED) Mascara 10.15 0.001015 0.025 3 1.27 × 10−6 2.5 1,970,443 Eye shadow 19.04 0.001904 0.02 3 1.90 × 10−6 2.5 1,313,025 Eyeliner 31.03 0.003103 0.005 3 7.76 × 10−7 2.5 3,222,688 Lipstick 62.19 0.006219 0.057 3 1.77 × 10−5 2.5 141,050 Body lotion 17.82 0.001782 7.82 3 6.98 × 10−4 2.5 3588 To calculate the MoS of Co, we used a dermal absorption value of 0.13% for Co and used NOAEL of 0.01 mg/kg bw/day (Table VI) (23,24). JOURNAL OF COSMETIC SCIENCE 320

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