Table V Cr MoS Calculation Cosmetic type Maximum detected Cr (μg/g) Maximum %Cr (g) Estimated daily amount applied (g/day) % Dermal absorption SED (mg/kg bw/day) NOAEL (mg/kg bw/day) MoS (NOAEL/SED) Mascara 10.15 0.001015 0.025 3 1.27 × 10−6 2.5 1,970,443 Eye shadow 19.04 0.001904 0.02 3 1.90 × 10−6 2.5 1,313,025 Eyeliner 31.03 0.003103 0.005 3 7.76 × 10−7 2.5 3,222,688 Lipstick 62.19 0.006219 0.057 3 1.77 × 10−5 2.5 141,050 Body lotion 17.82 0.001782 7.82 3 6.98 × 10−4 2.5 3588 To calculate the MoS of Co, we used a dermal absorption value of 0.13% for Co and used NOAEL of 0.01 mg/kg bw/day (Table VI) (23,24). JOURNAL OF COSMETIC SCIENCE 320

Table VI Co MoS Calculation Cosmetic type Maximum detected Co (μg/g) Maximum %Co (g) Estimated daily amount applied (g/day) % Dermal absorption SED (mg/kg bw/day) NOAEL (mg/kg bw/day) MoS (NOAEL/SED) Mascara 10.18 0.001018 0.025 0.13 5.51 × 10−8 0.01 181,351 Eye shadow 7.09 0.000709 0.02 0.13 3.07 × 10−8 0.01 325,486 Eyeliner 48.19 0.004819 0.005 0.13 5.22 × 10−8 0.01 191,549 Lipstick 1.44 0.000144 0.057 0.13 1.78 × 10−8 0.01 562,303 Body lotion 0.81 0.000081 7.82 0.13 8.23 × 10−5 0.01 7286 According to our results, all the MoS values for the metals tested were found to be higher than 100 that is accepted as a minimum value for safe use of a substance (19). ALLERGEN METALS IN COSMETICS 321

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