578 JOURNAL OF COSMETIC SCIENCE open acne, closed acne, papules, and pustules, decreased, and the pores, greasiness, and moisture levels also improved. The self-evaluation of the skin pores, greasiness, moisture, and comfort level also show a satisfying score after 4 weeks of usage. REFERENCES (1) S. F. Friedlander, H. E. Baldwin, A. J. Mancini, A. C. Yan, and L. F. Eichenfield, The acne continuum: an age-based approach to therapy, Semin. Cutan. Med. Surg., 30(3), Suppl, S6–S11 (2011). (2) H. C. Williams, R. P. Dellavalle, and S. Garner, Acne vulgaris, Lancet, 379(9813), 361–372 (2012). (3) D. E. Castillo, S. Nanda, and J. E. Keri. Propionibacterium (Cutibacterium) acnes bacteriophage therapy in acne: current evidence and future perspectives, Dermatol. Ther., 9(1), 19–31 (2019). (4) J. Fernández, C. Webb, K. Rouzard, J. Healy, M. Tamura, M. Voronkov, K. L. Huber, J. B. Stock, M. Stock, J. S. Gordon, and E. Pérez., SIG1459: A novel phytyl-cysteine derived TLR2 modulator with in vitro and clinical anti-acne activity, Exp. Dermatol., 27 (9), 993–999 (2018). (5) B. Dreno, R. Martin, A. Khammari, D. Moyal, J.B. Seite, and S. Seite, Skin microbiome and acne vulgaris: Staphylococcus, a new actor in acne. SKIN The Journal of Cutaneous Medicine, 1(3.1), 54 (2017). (6) A. Koreck, A. Pivarcsi, A. Dobozy, and L. Kemény, The role of innate immunity in the pathogenesis of acne, Dermatology, 206(2), 96–105 (2003). (7) R. G. Fried and A. Wechsler, Psychological problems in the acne patient, Dermatol. Ther., 19(4), 237– 240 (2010). (8) R. Balkrishnan, A. J. McMichael, J. Y. Hu, F. T. Camacho, K. R. Shew, A. Bouloc, S. R. Rapp, and S. R. Feldman, Correlates of health-related quality of life in women with severe facial blemishes, Int. J. Dermatol., 45(2), 111–115 (2010). (9) A. F. Klassen, J. N. Newton, and E. Mallon, Measuring quality of life in people referred for specialist care of acne: comparing generic and disease-specific measures, J. Am. Acad. Dermatol., 43(2 Pt 1)(2-part-P1), 229–233 (2000). (10) J. Koo, The psychosocial impact of acne: patients’ perceptions, J. Am. Acad. Dermatol,. 32(5 Pt 3), S26– S30 (1995). (11) R. J. Lasek and M. M. Chren, Acne vulgaris and the quality of life of adult dermatology patients, Arch. Dermatol., 134(4), 454–458 (1998). (12) L. Abu-Qatouseh, E. Mallah, and K. Mansour, Evaluation of anti-propionibacterium acnes and anti- inflammatory effects of polyphenolic extracts of medicinal herbs in Jordan, Biomedical and Pharmacol. J., 12(1), 211–217 (2019). (13) A. N. Lin and T. Nakatsui, Salicylic acid revisited, Int. J. Dermatol., 37(5), 335–342 (1998). (14) A. Tasleem, Salicylic acid as a peeling agent: a comprehensive review, Clin. Cosmet. Investig. Dermatol., 8, 455–461 (2015). (15) J. Lu, T. Cong, X. Wen, X. Li, D. Du, G. He, and X. Jiang., Salicylic acid treats acne vulgaris by suppressing AMPK/SREBP1 pathway in sebocytes, Exp. Dermatol., 28(7), 786–794 (2019). (16) M. A. Davies, Salicylic acid deposition from wash-off products: comparison of in vivo and porcine deposition models, Int. J. Cosmet., 37(5), 526–531 (2015). Table IV Parameters for Comfort and Tolerance Evaluation Parameters 1 2 3 4 The product is comfortable Totally agree Agree a little Sort of disagree Totally disagree The product does not cause tingling Totally agree Agree a little Sort of disagree Totally disagree The product does not cause tension Totally agree Agree a little Sort of disagree Totally disagree The product does not cause pimples Totally agree Agree a little Sort of disagree Totally disagree The product does not cause swelling Totally agree Agree a little Sort of disagree Totally disagree The product does not cause skin greasiness Totally agree Agree a little Sort of disagree Totally disagree The product does not cause skin stickiness Totally agree Agree a little Sort of disagree Totally disagree The product is easy to use Totally agree Agree a little Sort of disagree Totally disagree

579 ANTI-ACNE PERFORMANCE OF COSMETIC SKINCARE PRODUCTS (17) J. A. Zeichner, The use of lipohydroxy acid in skin care and acne treatment, J. Clin. Aesthet. Dermatol., 9(11): 40–43 (2016). (18) X. Liu, P. K. Tian, D. W. Ju, M. H. Zhang, M. Yao, X. T. Cao, and J. R. Gu, Systemic genetic transfer of p21WAF-1 and GM-CSF utilizing of a novel oligopeptide-based EGF receptor targeting polyplex, Cancer Gene Ther., 10(7), 529–539 (2003). (19) Y. Wu, G. Zhang, and M. Zhou, Inhibitory and anti-inflammatory effects of two antimicrobial peptides moronecidin and temporin-1Dra against propionibacterium acnes in vitro and in vivo, J. Pept. Sci., 26(7), e3255 (2020). (20) C. H. Yang, Y. C. Huang, Y. F. Chen, and M. H. Chang, Foam properties, detergent abilities, and long- term preservative efficacy of the saponins from Sapindus mukorossi, J. Food Drug Anal., 18(3), 155–160 (2010).