621 CENTELLA ASIATICA EXTRACTS IN SKIN REPAIR PRODUCTS (3) A. Niazi, V. B. Rahimi, Soheili-Far S, N. Askari, P. Rahmanian-Devin, Z. Sanei-Far, A. Sahebkar, H. Rakhshandeh, and V. R. Askari, A systematic review on prevention and treatment of nipple pain and fissure: are they curable? J. Pharmacopuncture, 21,139–150 (2018). (4) C. Gorzelanny, C. Mess, S. W. Schneider, V. Huck, and J. M. Brandner, Skin barriers in dermal drug delivery: which barriers have to be overcome and how can we measure them? Pharmaceutics, 12, 684 (2020). (5) A. Chamli and A. Souissi, “Lichen Sclerosus,” StatPearls, (StatPearls Publishing, Treasure Island, FL, January 2021), https://www.ncbi.nlm.nih.gov/books/NBK538246. (6) L. A. Sadownik, E. Koert, C. Maher, and K. B. Smith, A qualitative exploration of women’s experiences of living with chronic vulvar dermatoses, J. Sex Med. 9, 1740–1750 (2020). (7) J. M. Krapf, L. Mitchell, M. A. Holton, and A. T. Goldstein, Vulvar lichen sclerosus: current perspectives, Int. J. Women’s Health, 12, 11–20 (2020). (8) Y. Marfatia, A. Surani, and R. Baxi, Genital lichen sclerosus et atrophicus in females: an update, Indian J. Sex Transm. Dis. AIDS, 1, 6–12 (2019). (9) J. C. Kent, E. Ashton, C. M. Hardwick, M. K. Rowan, E. S. Chia, K. A. Fairclough, L. L. Menon, C. Scott, G. Mather-McCaw, K. Navarro, and D. T. Geddes, Nipple pain in breastfeeding mothers: incidence, causes and treatments, Int. J. Environ. Res. Public Health, 10, 12247–12263 (2015). (10) E. Berardesca, M. Farage, and H. Maibach. Sensitive skin: an overview, Int. J. Cosmet. Sci., 35, 2–8 (2013). (11) S. Seite and L. Misery, Skin sensitivity and skin microbiota: is there a link? Exp. Dermatol., 27, 1061– 1064 (2018). (12) J. James and I. Dubery, Identification and quantification of tripenoid centelloids in Centella asiatica (L.) urban by densitometric TLC, J. Planar Chromat., 24, 82–87 (2011). (13) World Health Organization, WHO Monographs on Selected Medicinal Plants, 2nd Ed. (WHO, Ravello- Salerno, Italy, 1999), pp. 77–85. (14) W. Bylka, P. Znajdek-Awiżeń, E. Studzińska-Sroka, A. Dańczak-Pazdrowska, and M. Brzezińska. Centella asiatica in dermatology: an overview, Phytother. Res., 28, 1117–1124 (2014). (15) A. Ratz-Łyko, J. Arct, and K. Pytkowska, Moisturizing and antiinflammatory properties of cosmetic formulations containing Centella asiatica extract, Indian J. Pharm. Sci., 78, 27–33 (2016). (16) L. Suguna, P. Sivakumar, and G. Chandrakasan, Effects of Centella asiatica extract on dermal wound healing in rats, Indian J. Exp. Biol., 34, 1208–1211 (1996). (17) Sunilkumar, S. Parameshwaraiah, and H. G. Shivakumar. Evaluation of topical formulations of aqueous extract of Centella asiatica on open wounds in rats, Indian J. Exp. Biol., 36, 569–572 (1998). (18) A. Shukla, A. M. Rasik, G. K. Jain, R. Shankar, D. K. Kulshrestha, and B. N. Dhawan, In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica, J. Ethnopharmacol., 65, 1–11 (1999). (19) L. C. Agra, J. N. Ferro, F. T. Barbosa, and E. Barreto, Triterpenes with healing activity: a systematic review, J. Dermatolog. Treat., 26, 465–470 (2015). (20) O. Ozdemir, K. Ozkan, F. Hatipoglu, A. Uyaroglu, and M. Arican, Effect of asiaticoside, collagenase, and alpha-chymotrypsin on wound healing in rabbits, Wounds, 28, 279–286 (2016). (21) M. F. Nagoor Meeran, S. N. Goyal, K. Suchal, C. Sharma, C. R. Patil, and S. K. Ojha, Pharmacological properties, molecular mechanisms, and pharmaceutical development of asiatic acid: a pentacyclic triterpenoid of therapeutic promise, Front Pharmacol., 9, 982 (2018). (22) R. Cotellese, S. Hu, G. Belcaro, A. Ledda, B. Feragalli, M. Dugall, M. Hosoi, and E. Ippolito, Centella asiatica (Centellicum®) facilitates the regular healing of surgical scars in subjects at high risk of keloids, Minerva Chir., 73, 151–156 (2018). (23) J. Somboonwong, M. Kankaisre, B. Tantisira, and M. H. Tantisira, Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study, BMC Complement Altern. Med., 12, 103 (2012). (24) J. H. Sampson, A. Raman, G. Karlsen, H. Navsaria, and I. M. Leigh. In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins, Phytomedicine, 8, 230–235 (2001). (25) H. S. Datta and R. Paramesh, Trends in aging and skin care: ayurvedic concepts, J. Ayurveda Integr. Med., 1, 110–113 (2010). (26) I. S. An, S. An, S. M. Kang, T. B. Choe, S. N. Lee, H. H. Jang, and S. Bae, Titrated extract of Centella asiatica provides a UVB protective effect by altering microRNA expression profiles in human dermal fibroblasts, Int. J. Mol. Med., 30, 1194–1202 (2012). (27) F. X. Maquart, F. Chastang, A. Simeon, P. Birembaut, P. Gillery, and Y. Wegrowski. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds, Eur. J. Dermatol., 9, 289–296 (1999).

622 JOURNAL OF COSMETIC SCIENCE (28) N. P. Luepke and F. H. Kemper, The Het-Cam test: an alternative to the Draize eye test, Food Chem. Toxicol., 24, 495–496 (1986). (29) F. N. Marzulli and H. I. Maibach, Contact allergy: predictive testing in man, Contact Dermatitis, 2, 1–17 (1976). (30) E. M. Jackson and N. F. Robillard, The controlled use test in a cosmetic product safety substantation program, J.Toxicol.Cut. Ocular. Toxicol., 20, 117–132 (1982). (31) B. Jackwerth, H. U. Krächter, and W. Matthies. Dermatological test methods for optimising mild tenside preparations, Parfümerie und Kosmetik, 74, 134–141 (1993). (32) B. H. Keswick, K. D. Ertel, and M. O. Visscher, Comparison of exaggerated and normal use techniques for assessing the mildness of personal cleansers, J. Soc. Cosm. Chem., 43, 187–193 (1992).