617 CENTELLA ASIATICA EXTRACTS IN SKIN REPAIR PRODUCTS In 11 children that presented skin irritation during the study on the face, untreated diaper zone, or rest of the body, the irritation disappeared in all cases after application of the product within 24 h in four children, 2–3 d in five children, and in over 3 d in the two remaining children. Furthermore, 10 parents (91%) of these children considered that the product favored skin repair, alleviated reddening, and repaired rubbing or friction (chafing) zones. These results are detailed in Table IV and Figure 5. Lastly, according to the clinical Table I Results Referring to the Anti-irritant, Skin Barrier Function Repair, and Epidermal Cell Renewal Effects of Blastoactiva™ Variable Forearm control Forearm treated Difference p valuea Intensity of erythema (anti-irritant) Colorimetry, % variation D2 versus D1 7 ± 28% 9 ± 32% 2 ± 24% 0.989 “Reactive”b subjects, n = 31 (11%) –27% D3 versus D1 10 ± 28% 10 ± 33% 0 ± 21% 0.585 “Reactive” subjects, n = 14 (39%) –22% Assessment by clinical inspection D2 versus D1 0.0 ± 1.1 –0.2 ± 1.3 –0.2 ± 0.9 0.181 “Reactive” subjects 11 (31%) D3 versus D1 –0.2 ± 1.2% –0.6 ± 1.4% –0.4 ± 0.9% 0.031 “Reactive” subjects 13 (36%) Repair of skin barrier function, % variation TEWL D2 versus D1 14.3 ± 40.7% –9.5 ± 28.7 –23.8 ± 29.9 0.001 “Reactive” subjects, n = 26 (72%) 34% D3 versus D1 5.5 ± 36.7% –23.1 ± 29.8% –28.6 ± 28.1% 0.001 “Reactive”subjects, n = 26 (72%) 37.8% Epidermal cell renewal ITA angle, D3 14.9 ± 8.6 14.9 ± 8.6 0.01 ITA angle, D14 39.1 ± 11.8 45.3 ± 6.8 D1, 1 h after removal of the patches and before application of the product D2, after 24 h D3, after 48 h TEWL, transepidermal water loss ITA, individual typological angle. a Student t-test or Mann-Whitney U-test. b “Reactive” subjects D2 versus D1 or D3 versus D1 in treated zone and control zone ≤10% or 0 in case of assessment by clinical inspection. Table II Assessment of the Cosmetic Qualities of the Product (Blastoactiva™) Item of the questionnaire Percentage of subjects who agree or very much agree Has a pleasant texture 94 Leaves the skin feeling soft and smooth 89 Hydrates the skin 83 Has a pleasant smell 83 The product is rapidly absorbed 86 Leaves no residue on the skin 94 Not oily 92 Does not stain clothing 100 It has satisfied me 83 It is a unisex product 100

618 JOURNAL OF COSMETIC SCIENCE evaluation by dermatologists, pediatricians, and ophthalmologists, Blastoactiva™ was well tolerated by the skin and eyes with no recorded adverse reactions attributable to the product. Thus, Blastoactiva™ has been found to be effective against irritation, exerting skin barrier function repair effects, and enhancing epidermal cell renewal capacity in the adult population. Likewise, in the pediatric population, the product has been found to be effective in treating damaged skin (e.g., diaper rash), well accepted from the parent point of view, and well tolerated as assessed by the dermatologist, pediatrician, and ophthalmologist. Table III Results of the Cosmetic Qualities and Efficacy Evaluations Aspect evaluated Number (%) of observing parents Strongly agree Somewhat agree Somewhat disagree Strongly disagree Cosmetic qualities General application of the product on the skin is easy 18 (81.2) 3 (13.6) 1 (4.6) 0 The product has a pleasant smell 13 (59.1) 6 (27.3) 3 (13.6) 0 The product has a pleasant texture 14 (63.4) 8 (36.4) 0 0 The product spreads easily on the skin 16 (72.3) 5 (22.7) 1 (4.6) 0 The product is rapidly absorbed 14 (63.6) 6 (27.3) 1 (4.6) 1 (4.6) The product does not leave a sticky sensation on the skin 17 (77.3) 5 (22.7) 0 0 The product does not leave an oily sensation on the skin 15 (68.2) 6 (27.3) 1 (4.6) 0 The product does not stain clothing 14 (63.6) 6 (27.3) 1 (4.6) 1 (4.6) Cosmetic efficacy Suitable for daily infant care 18 (81.8) 4 (18.2) 0 0 Suitable for application in diaper friction zones (waist, groin) 16 (72.7) 5 (22.7) 1 (4.6) 0 The skin of the infant is softer in the treated zone 14 (63.6) 8 (36.4) 0 0 I have noticed less irritation in the treated zones (groin, waist) with use of the product (evaluated in nine infants) 6 (66.7) 2 (22.2) 1 (11.1) 0 The product has avoided reddening and friction in the treated zones (groin, waist) (evaluated in nine infants) 7 (77.8) 1 (11.1) 1 (11.1) 0 General applicag415on of the product on the skin is easy The product has a pleasant smell The product has a pleasant texture The product spreads easily on the skin Figure 2. Results of the cosmetic qualities evaluation in the efficacy and acceptability study of Blastoactiva™ in pediatric population. Percentage (%) of parents satisfied