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J. Soc. Cosmetic Chemists, 16, 341-348 (1965) Soluble Brominated Salicylanilides W. E. LANGE, Ph.D.,':' and M. R. MEZIKOFSKY, M.S.t Presented at the American Pharmaceutical Association Meeting, August 8-6, 19•, New York City Synopsis The low aqueous solubility of the brominated salicylanilides (x) limits their use- fulness in cosmetic or pharmaceutical preparations. Nonionic surface active agents and compounds chemically related to • did not increase solubility. Preparation of the salts of • gave compounds with good microbiological activity and aqueous solubility but with limited light stability. Aqueous solutions of formulations utilizing the salts of x showed good sta- bility when they were protected from U.V. light. INTRODUCTION Antimicrobial agents are used in many cosmetic and pharma- ceutical products to protect and preserve them from deterioration due to growth of bacteria, fungi, or yeasts. Many of the higher mo- lecular weight agents such as hexachlorophene, dichlorophene, bithionol, the parabens and substituted salicylanilides have extremely low water solubilities. Because of their low water solubility their use is somewhat limited. Thus, with the great interest today in the salicylanilides it was thought that the preparation of a water soluble compound or mixture would be of value in product formulations. Recently, considerable interest has centered about the halonitro- salicylanilides (1) and halogenated salicylanilides, especially various chlorinated and brominated derivatives (2, 3). The halogenation of the salicylanilide molecule enhances the activity of the parent compound (4). * Massachusetts College of Pharnmey, Boston, Mass. i Gillette Safety Razor Co., Boston, Mass. 341