ANALYSIS OF PARABENS BY LIQUID CHROMATOGRAPHY Table V Analytical Results on Typical Suspension Samples 387 Per Cent Per Cent Sample Methylparaben Propylparaben Number of Trials 1 0.105% 0.052% l 2 0.099% q- 1.0% RSD a 0.054% _ 1% 2 3 0.101% q- 1.0% 0.054% _ 1% 3 4 0.102% q- 1.5% 0.048% _ • 1% 2 theory 0.100% 0.050% For duplicate assays RSD • range 100 X 2 Average aRSD means relative standard deviation SUMMARY An HPLC method has been developed, which allows rapid, accurate, and precise quantitation of the paraben preservatives in emulsion and suspension systems. Average relative standard deviations of less than 3% are typical for methylparaben and propylparaben at levels ranging from 0.05-to-0.2% w/w. Sample preparation is minimal, a decided advantage when analyzing complex mixtures. The method illustrates that HPLC is a valuable analytical method for quantitative analysis in quality control and stability testing. The tech- nique should be considered for more widespread application in the analysis of cosmetic products. (Received October 24, 1974) REFERENCES (1) C. P. Talley, High-sr•eed ion exchange chromatography of several mono-substituted pyridine isomers, Anal. Chem., 43, 1512-4 (1971). (2) C. Y. Wu and S. Siggia, Analysis of purine and strychnos alkaloids by high speed liquid chromatography, Anal. Chem., 44, 1499-1501 (1972). (3) T. C. Kram, Separation of sulfa drugs by high speed liquid chromatography, J. Pharm. Sci., 61, 254-56 (1972). (4) R. W. Ross, Identification and determination of synthetic estrogens in pharmaceu- ticals by high-speed, reversed-phase partition chromatography, J. Pharm. Sci., 63, 594-9 (1974). (5) P. Casman, J. Thornton, and D. Shelman, High pressure liquid chromatographic separation of phenetylamines of forensic interest, J. Chrom. Sci., 11, 7-9 (1973). (6) J. J. Nelson, Quantitation of sodium saccharin, sodium benzoate and other food ad- ditives by high speed liquid chromatography, J. Chrom. Sci, 11, 28-35 (1973). (7) M. Batchelder, H. Tarlin, and G. Williamson, Chromatographic separation and de- termination of methyl p-hydroxybenzoate, J. Pharm. Sci., 61, 252-3 (1972).

388 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Society of Cosmetic Chemists Award Sponsored by International Flavors and Fragrances, Inc. The Society of Cosmetic Chemists Award sponsored by Interaatioaal Flavors and Fragrances, Inc., for the most meritorious paper published in the Journal of the Soc.•ety of Cosmetic Chemists, USA, in the year 1974 •vas presented to Dr. Eric Jungermann, Vice-President of Research and Devel- opment, Armour-Dial Inc. The formal presentation of a scroll and a $1,000 honorarium •vas made by Mr. Monroe Lanzet, A•vard Chairman, at the \'lay 29, 1975 luncheon of the Society of Cosmetic Chemists Seminar, held at the Chase Park Plaza, St. Louis, Mo. Dr. Jungermann's a•vard •vinning paper •vas entitled: "Antiperspirants: New Trends in Formulation and Testing Technology." Left to right: Mr. Stephen Hoch, SCC President, Albert Vedey & Co. Dr. Eric Junger- mann, Award Winner, Armour-Dial, Inc. and Mr. Monroe Lanzet, Award Chairman, Cosmair, Inc.