EVALUATION OF OCULAR DECONGESTANTS IN RABBITS 405 Table III Ocular Decongestant Dose Ranges in Rabbits Elfect Control 15 See 1 Min 2 Min 1.0% Hydroxyamphetamine HBr Conjunctival redness 2 2 1 0 Chemosis 1 0 0 0 Pupil diameter (mm) 7 7 7 7 Conjunctival redness Chemosis Pupil diameter (ram) 2 2 1 0 1 0 0 0 7 7 7 7 Conjunctival redness Chemosis Pupil diameter (mm) 0.1% Hydroxyamphetamine HBr Conjunctival redness Chemosis Pupil diameter (mm) 2 ! 1 0 1 0 0 0 6 6 6 6 3 2 o o o o o o 6 6 6 6 Conjunctival redness Chemosis Pupil diameter (ram) 2 1 1 0 0 0 0 0 6 6 6 6 Conjunctival redness Chcmosis Pupil diameter (ram) 0.01% Hydroxyamphetamine HBr Conjunctival redness Chemosis Pupil diameter (mm) 2 1 1 0 0 0 0 0 7 7 7 7 2 2 1 1 0 0 0 0 7 7 7 7 Conjunctival redness Chemosis Pupil diameter (ram) 3 2 1 1 1 1 0 0 7 7 7 7 Coniunctival redness Chemosis Pupil diameter (mm) 2 1 1 0 1 1 1 0 6 6 6 6 (continued)

406 JOURNAL OF THE SOCIETY OF COSMETIC CHEMISTS Table III (continued) Effect Control 15 See i Min 2 Min 0.4% Chlorpheniramine Maleate (Base) Conjunctival redness 2 2 1 0 Chemosis 1 1 0 0 Pupil diameter (mm) 7 7 7 7 Conjunctival redness 2 2 i 1 Chemosis 0 0 0 0 Pupil diameter (mm) 7 7 7 7 Conjunctival redness 2 2 i 1 Chemosis 0 0 0 0 Pupil diameter (mm) 8 8 8 8 0.3% Chlorpheniramine Maleate (Base) Conjunctival redness 2 2 i 1 Chemosis I i 0 0 Pupil diameter (mm) 5 5 5 6 Conjunctival redness 2 2 2 1 Chemosis 0 0 0 0 Pupil diameter (mm) 5 5 5 5 Conjunctival redness 2 2 2 1 Chemosis 0 0 0 0 Pupil diameter (mm) 5 5 5 5 0.2% Chlorpheniramine Maleate (Base) Conjunctival redness 2 2 2 1 Chemosis i I i 0 Pupil diameter (mm) 8 8 8 8 Conjunctival redness 2 2 2 2 Chemosis 0 0 0 0 Pupil diameter (mm) 8 8 8 8 Conjunctival redness 2 2 2 1 Chemosis 1 1 0 0 Pupil diameter (ram) 7 7 7 7 Placebo Conjunctival redness 2 2 2 2 Chemosis 1 1 1 1 Pupil diameter (ram) 7 7 7 7 Conjunctival redness 2 2 2 2 Chemosis 0 0 0 0 Pupil diameter (mm) 7 7 7 7 Con/unctival redness 3 3 3 3 Chemosis 0 0 0 0 Pupil diameter (ram) 6 6 6 6