EVALUATION OF OCULAR DECONGESTANTS IN RABBITS 409 min. It was noted that some formulations cleared the eye in 9. min. These eyes would be stable at 30 min posttest. However, when challenged, they would re- spond with an irritation reaction. Thus this was interpreted to indicate that a cleared eye would be stable if not repeatedly insulted. It was found that the addition of hydroxypropylmethyleellulose, 0.5% or less, could confer longer duration of activity to a formula containing an effective concentration of hy- droxyamphetamine HBr. This was determined with 30 min repeated insults with 5% sodium chloride. Hydroxypropylmethyleellulose is now employed to significantly prolong the duration of action of opthalmie preparations (5), and other agents are also suggested for the same purpose (2). CONCLUSIONS An assay has been developed to test standard and experimental ocular de- congestant formulas in rabbits. This assay is capable of discriminating the de- gree of activity for chemicals and formulations under consideration for use as ocular decongestants. (Received December 3, 1974) REFERENCES (1) J. H. Draize, Appraisal of the safety of chemicals in foods, drugs, and cosmetics, Association of Food and Drug officials of the United States, Austin, Texas, 1959, p. 51. (2) P. W. Lofholm, Handbook of Non-Prescription Drugs, G. B. Griffenhasen and L. L. Hawkins, Eds., American Pharmaceutical Association, Washington, D.C., 1973, p. 99. (3) 1t. A. Moses, Adter's Physiology of the Eye, 5th ed., C. V. Mosby Co., St. Louis, 1970, p. 399. (4) P. P. Ellis and D. L. Smith, Handbook of Ocular Therapeutics and Pharmacology, 4th ed., C. V. Mosby Co., St. Louis, 1973, p. 196. (5) W. H. Haveher, Ocular Pharmacology, 2nd ed., C. V. Mosby Co., St. Louis, 1970, pp. 403-5.

410 JOURNAL OF TIlE SOCIETY OF COSMETIC CHEMISTS Society of Cosmetic Chemists Award Sponsored by Shaw Mudge and Co. The Society of Cosmetic Chemists Award, sponsored by Shaw Mudge and Company, for contribut:ons to safety in the use of toiletry and cos- metic products, was awarded to Dr. Albert M. Kligman, Professor of Der- matology, University of Pennsylvania School of Medicine for his outstand- ing paper titled "Identification of Contact Allergens by Human Assay. Part III--The Maximization Test: A Procedure for Screening and Rating Contact Sens-tizers." The formal presentation of a scroll and a $1,000 honorarium was made by Mr. George Pollack standing in for Mr. Clyde Burnett, Award Chairman, at the May 29, 1975 luncheon during the Society of Cosmetic Chemists Sem- inar at the Chase Park Plaza, St. Louis, Mo. ß '•,,!:%,:.. "...' . -.•, "}•!:. %,..?.-. :.i.i. •d :." •, ....... • ..... .-.i• '. ., •: . ':.•. -•... • :•... .. •.•- . ::::::½,::....•.:.5 ..½.:.: .. :. Left to right: Mr. Stephen Hoch, SCC President, Albert Verley & Co. Dr. Albert M. Kligman, Award Winner, University of Pennsylvania Medical School Mr. George Pol- lack, L'Oreal of Paris Products, standing in for Award Chairman, Clyde Burnett, Clairol, Inc.