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J. Cosmet. Sci., 64, 329–340 (September/October 2013) 329 Moisturizing effect of topical cosmetic products applied to dry skin JANA POLASKOVA, JANA PAVLACKOVA, PAVLINA VLTAVSKA, PAVEL MOKREJS, and RAHULA JANIS, Department of Fat, Tenside, and Cosmetics Technology ( J.P., J.P., P.V., R.J.), and Department of Polymer Engineering (P.M.), Tomas Bata University in Zlin, 762 72 Zlin, Czech Republic. Accepted for publication march 18, 2013 Synopsis One of the complications of “diabetes mellitus” is termed diabetic foot syndrome, the fi rst symptoms of which include changes in the skin’s condition and properties. The skin becomes dehydrated, dry, and prone to excessive formation of the horny layer, its barrier function becoming weakened. This function can be re- stored by applying suitable cosmetic excipients containing active substances. The aim of this study was to evaluate and compare the effects of commercially available cosmetic products (CPs) designed for the care of diabetic foot, through a group of selected volunteers using noninvasive bioengineering methods. Statistical surveys (p 0.05) evaluated these CPs as regards to their hydration effect and barrier properties. Special at- tention was devoted to CPs with the declared content of 10% urea, and that the infl uence of this preparation’s ability to hydrate and maintain epidermal water in the epidermis was confi rmed. INTRODUCTION Diabetes mellitus (DM) belongs to a group of heterogeneous diseases. The World Health Organization defi nes DM as a state of chronic hyperglycemia, which may be caused by a number of exogenous and endogenous factors acting simultaneously. The clinical course of each type of DM is highly variable, but a single common characteristic is the presence of hyperglycemia, which occurs on the basis of insuffi cient action of insulin in the tissues. Abnormalities, however, occur in the metabolism of fat and protein as well, in addition to those in electrolyte and water management of the body (1–3). DM, like other endo- crine disorders, may be the cause of changes in the function and properties of the skin. Skin complications occur in approximately 30% of patients and may also be the fi rst sign of DM. Hyperglycemia and reduced insulin are factors involved in deterioration of skin function, causing the skin of patients with DM to decrease hydration capacity, in addition to reducing the activity of the sebaceous glands (4,5). DM causes glycosylation products Address all correspondence to Jana Pavlackova at pavlackova@ft.utb.cz.