JOURNAL OF COSMETIC SCIENCE 82 RESULTS IN VITRO EFFECTS ON IL-8 The associations of Rhamnose 0.5%–mannitol 0.5%–xylitol 0.5% and rhamnose 0.05%– mannitol 0.1%–xylitol 0.1% associations inhibited IL-8 synthesis, respectively, from 24.8% (p 0.001) and 22.2% (p 0.01). CLINICAL STUDY IN FRANCE Thirty-three women were included in the study. The mean age was 47 (21–74) years. Sensibio Tolerance +® was applied by patients to the entire face twice a day for 28 days. The stinging score decreased from 4.3 (±0.2) to 1.7 (±0.4) after 4 weeks (-62% p 0.0001) (Fig. 1). An immediate soothing effect was showed by a decrease (p 0.0001) in the stinging score after one application from 1.6 (±0.1) to 0.3 (±0.1) after 5 min (-80%), and to 0.03 (±0.03) after 15 min (-98.1%) (Fig. 2). The erythema score decreased from 2.5 (±0.1) to 1.8 (±0.2) after 4 weeks (-25% p 0.0001) (Fig. 3). The DLQI score decreased from 3.3 (±0.8) to 0.9 (±0.2) after 4 weeks (-74% p 0.0001). No pertinent side effects were noticed after 4 weeks of application. The patients gave a score of around 7/10 or 8/10 for the cosmetic qualities of the product and excipient (data not shown). CLINICAL STUDY IN THAILAND Thirty women were included in the study. The mean age was 39 (20–51) years. The cosmetic product was applied by patients to the entire face twice a day for 28 days. The stinging score decreased from 3.7 (±0.2) to 1.4 (±0.2) after 4 weeks (-62.2% p 0.0001) (Fig. 1). An immediate soothing effect was showed by a decrease (p 0.0001) in the stinging score after one application of Sensibio Tolérance +® from 1.7 (±0.1) to 0.5 (±0.1) after 5 min (-70.6%) and 0.3 (±0.1) after 15 min (-82.4%) (Fig. 4). There was a signifi cant difference (p 0.0001) when the product was not applied: 1.7 (±0.1) Figure 1. Preventive soothing effect.

NEW TOPICAL COMBINATION ON SENSITIVE SKIN 83 to 1.2 (±0.1), then 0.7 (±0.2). Moreover, soothing effect duration was longer than that on the control side: 14.2 min versus 8 min (-44%, p 0.0001). The erythema score decreased from 0.3 (±0.1) to 0.1 (±0.0) after 4 weeks, but no statistical analysis was applicable because less than a third of the patients had a variation between day 0 and day 28 (data not shown). The DLQI score decreased from 4.3 (±1.2) to 0.8 (±0.3) after 4 weeks (81.4% p 0.001). No pertinent side effects were noticed after 4 weeks of application. The patients gave a score of around 8/10 for the cosmetic qualities of the product (data not shown). CAPSAICIN TEST Twenty-two volunteers were included in the study. The mean age was 31 (18–64) years. After using the product twice a day for 28 days, the tolerated concentration of capsaicin increased from 1.10−4% to 3.16.10−4% (p 0.01), indicating that the tolerance threshold was higher. SLS TEST Twenty volunteers were included in this study. Twenty-four hours after using Sensibio Tolérance+®, redness signifi cantly decreased (p 0.01) by 79% compared with placebo and 1% of SLS. Photographs were taken in all cases. Patient number 7 at 24 h was given as an example (Fig. 5). Figure 2. Immediate soothing effect on Caucasian skin. Figure 3. Soothing effect on erythema on Caucasian skin.